41860-64-4

Basic information

• Product Name: 4-Fluoro-2-iodo-1-nitrobenzene
• Synonyms: 4-Fluoro-2-iodo-1-nitrobenzene;4-Fluoro-2-iodo-1-nitrobenzene ,95%;Benzene, 4-fluoro-2-iodo-1-nitro-
• CAS NO: 41860-64-4
• Molecular Formula: C₆H₃FINO₂
• Molecular Weight: 266.9963932
• Mol File: 41860-64-4.mol

Chemical Properties

• Melting Point: 30 °C
• Boiling Point: 148°C/20mmHg(lit.)
• Appearance: /
• Density: 2.093±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-Fluoro-2-iodo-1-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-2-iodo-1-nitrobenzene(41860-64-4)
• EPA Substance Registry System: 4-Fluoro-2-iodo-1-nitrobenzene(41860-64-4)

Safety Data

• Hazardous Substances Data: 41860-64-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-Fluoro-2-iodo-1-nitrobenzene is used as a key intermediate in the synthesis of various organic compounds and materials. Its distinct functional groups allow for a wide range of chemical reactions, facilitating the creation of new molecules with diverse properties and applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-fluoro-2-iodo-1-nitrobenzene is utilized as a building block for the development of new drugs. Its unique structure and reactivity enable the design and synthesis of novel pharmaceutical compounds with potential therapeutic effects.
Used in Dye and Paint Production:
4-Fluoro-2-iodo-1-nitrobenzene is employed as a starting material in the production of dyes and paints. Its chemical properties contribute to the development of colorants with specific characteristics, such as brightness, stability, and solubility.
Used in Agricultural Chemicals:
In the agricultural sector, 4-fluoro-2-iodo-1-nitrobenzene serves as a precursor for the synthesis of various agrochemicals. Its potential applications include the development of pesticides, herbicides, and other crop protection agents, enhancing agricultural productivity and crop protection.

InChI:InChI=1S/C6H3FINO2/c7-4-1-2-6(9(10)11)5(8)3-4/h1-3H

Upstream product

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Downstream Products

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• 2369-11-1 5-fluoro-2-nitroaniline 
• 1089279-33-3 4-fluoro-1-nitro-2-(2-propen-1-yl)benzene 

Relevant articles and documents

Synthetic method of aryl halide taking aryl carboxylic acid as raw material

A synthetic method of an aryl halide taking aryl carboxylic acid as a raw material is characterized in that a corresponding aryl halide is formed by carrying out substitution reaction on an aryl carboxylic acid compound and haloid salt MX in an organic solvent under the condition that oxygen, a silver catalyst, a copper additive and a bidentate nitrogen ligand exist, wherein M in MX represents alkali metal or alkaline earth metal, and X represents F, Cl, Br or I. Compared with a conventional aryl halide synthetic method, the synthetic method disclosed by the invention has the obvious advantages that reaction raw materials (comprising aryl carboxylic acid and MX) are cheap and easy to obtain, the using amount of a metal catalyst is small, pollution to the environment when the oxygen is used as an oxidant is the smallest, good tolerance to various functional groups on an aromatic ring is obtained, the yield is high, and the like. The synthetic method disclosed by the invention can be widely applied to synthesis in the fields of medicine, materials, natural products and the like in industry and academia.

Decarboxylative Halogenation and Cyanation of Electron-Deficient Aryl Carboxylic Acids via Cu Mediator as Well as Electron-Rich Ones through Pd Catalyst under Aerobic Conditions

Simple strategies for decarboxylative functionalizations of electron-deficient benzoic acids via using Cu(I) as promoter and electron-rich ones by employing Pd(II) as catalyst under aerobic conditions have been established, which lead to smooth synthesis of aryl halides (-I, Br, and Cl) through the decarboxylative functionalization of benzoic acids with readily available halogen sources CuX (X = I, Br, Cl), and easy preparation of benzonitriles from decarboxylative cyanation of aryl carboxylic acids with nontoxic and low-cost K4Fe(CN)6 under an oxygen atmosphere for the first time.

Highly stereoselective 7-endo-trig /ring contraction cascade to construct pyrrolo[1,2- a ]quinoline derivatives

With the cooperation of Cram's phenonium ion, a novel cascade reaction was illustrated to construct pyrrolo[1,2-a]quinolines as a sole diastereoisomer in good to excellent yields. Preliminary mechanistic studies revealed that the γ-lactam ring and electron-rich arene are important driving forces for ring contraction.

Imidazopyridine Kinase Inhibitors

The present invention provides imidazopyridine compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

THE FOUR 6-HALO-7-NITROQUINOXALINES

The study of relative nucleofugicities of nitro and halogen in quinoxalines required the synthesis of the four 6-halo-7-nitroquinoxalines 2a-d.The fluoro-, chloro- and bromo-derivatives were made from the commercially available or readily accessible 1,2-diamino-4-halobenzenes, using the nitration of the corresponding p-toluenesulfonamides.This scheme failed in the case of the iodo compound because of extensive nitro-deiodination.The synthesis of 6-iodo-7-nitroquinoxaline was finally achieved from m-fluoroiodobenzene by taking advantage of the high reactivity of fluorine, compared to iodine, in 2,4-dinitrohalobenzenes.