- Easy access to drug building-blocks through benzylic C-H functionalization of phenolic ethers by photoredox catalysis
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A visible light-mediated photocatalyzed C-C-bond forming method for the benzylic C-H functionalization of phenolether containing synthetic building blocks based on a radical-cation/deprotonation strategy is reported. This method allows the mild, selective generation of benzyl radicals in phenolic complex molecules and drug-like compounds, providing new entries in synthetic and medicinal chemistry.
- Brandhofer, Tobias,Derdau, Volker,García Manche?o, Olga,Méndez, María,P?verlein, Christoph,Stinglhamer, Martin
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supporting information
p. 6756 - 6759
(2021/07/13)
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- AGRICULTURAL PLANT-PROTECTING AGENTS CONTAINING DIPEPTIDE DERIVATIVE AS ACTIVE INGREDIENT
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Provided is an agricultural plant-protecting agent including a dipeptide derivative or an agro-pharmaceutically acceptable salt thereof as an active ingredient, which has a plant disease-preventing effect, a plant growth-promoting effect, and a plant immunity-activating effect.
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Paragraph 0118; 0119
(2015/05/05)
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- Amino acid and peptide synthesis and functionalization by the reaction of thioacids with 2,4-dinitrobenzenesulfonamides
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(Formula Presented) Readily prepared amino thioacids react at room temperature in DMF in the presence of cesium carbonate with 2,4- dinitrobenzenesulfonamides to give amides. When the sulfonamide is derived from an amino acid the method results in peptide bond formation, whereas the use of carbohydrate derived sulfonamides gives neoglycoconjugates.
- Crich, David,Sana, Kasinath,Guo, Songpo
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p. 4423 - 4426
(2008/03/12)
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- On the fate of the tryptophan stereocenter during the synthesis of hexacyclic analogues of N-acetylardeemin
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The reaction between 6-acetyl-3-alkyl-1-ethoxy-3,4,5a,6,11,11a- hexahydro-10bH-pyrazino-[2',1'-5,1]pyrrolo-[2,3-b]indole-1,4-diones and anthranilic acid was studied from a stereochemical point of view. Various degrees of epimerization of the tryptophan an
- Caballero, Esmeralda,Avendano, Carmen,Menendez, J. Carlos
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p. 3025 - 3038
(2007/10/03)
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