- Palladium-catalyzed remote C-H functionalization of 2-aminopyrimidines
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A straightforward strategy was developed for the arylation and olefination at the C5-position of the N-(alkyl)pyrimidin-2-amine core with readily available aryl halides and alkenes, respectively. This approach was highly regioselective, and the transformation was achieved based on two different (Pd(ii)/Pd(iv)) and (Pd(0)/Pd(ii)) catalytic cycles.
- Das, Animesh,Jana, Akash,Maji, Biplab
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supporting information
p. 4284 - 4287
(2020/04/27)
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- COMPOSITIONS PROVIDING ENHANCED ANTIBACTERIAL ACTIVITY AGAINST GRAM-POSITIVE BACTERIA AND USE THEREOF
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A method of inhibiting, reducing growth of or destroying gram positive bacteria comprising contacting the gram positive bacteria with an effective amount of a 2-(substituted-amino)-imidazole compound and with an additional antibacterial compound separatel
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Page/Page column 18
(2020/09/08)
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- Structure-activity relationship of 4(5)-aryl-2-amino-1 H -imidazoles, N 1-substituted 2-aminoimidazoles and imidazo[1,2- a ]pyrimidinium salts as inhibitors of biofilm formation by salmonella typhimurium and pseudomonas aeruginosa
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A library of 112 4(5)-aryl-2-amino-1H-imidazoles, 4,5-diphenyl-2-amino-1H- imidazoles, and N1-substituted 4(5)-phenyl-2-aminoimidazoles was synthesized and tested for the antagonistic effect against biofilm formation by Salmonella Typhimurium and Pseudomo
- Steenackers, Hans P. L.,Ermolatev, Denis S.,Savaliya, Bharat,De Weerdt, Ami,De Coster, David,Shah, Anamik,Van Der Eycken, Erik V.,De Vos, Dirk E.,Vanderleyden, Jozef,De Keersmaecker, Sigrid C. J.
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experimental part
p. 472 - 484
(2011/04/15)
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- A divergent synthesis of substituted 2-aminoimidazoles from 2-aminopyrimidines
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(Chemical Equation Presented) A new divergent and efficient synthesis of substituted 2-aminoimidazoles 5 and 6 has been developed starting from the readily available 2-aminopyrimidines 1 and α-bromocarbonyl compounds 2, using conventional heating or microwave irradiation. Thus, the cleavage of 1,2,3-substituted imidazo[1,2-a]pyrimidin-1-ium salts 4 with hydrazine or secondary amines led to 1,4,5-trisubstituted 2-aminoimidazoles 5, when the hydrazinolysis of 2-hydroxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium salts 3, followed by a novel Dimroth-type rearrangement, resulted in formation of 2-amino-1H-imidazoles 6. The relevant pathway of transformations was identified by characterization of the intermediates.
- Ermolat'ev, Denis S.,Van Der Eycken, Erik V.
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p. 6691 - 6697
(2008/12/22)
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- Gas-phase pyrolytic reactions of N-ethyl, N-isopropyl, and N-t-butyl substituted 2-aminopyrazine and 2-aminopyrimidine
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The rates of gas-phase elimination of N-ethyl (1), N-isopropyl (2), N-t-butyl (3) substituted 2-aminopyrazine and N-ethyl (4), N-isopropyl (5), and N-t-butyl (6) substituted 2-aminopyrimidine have been measured. The compounds undergo unimolecular first-order pyrolytic reactions. The relative rates of the primary:secondary:tertiary alkyl homologues at 600 K are 1:14.4:38.0 for the pyrazines and 1:20.8:162.5 for the pyrimidines, respectively. The reactivities of these compounds have been compared with those of the alkoxy analogues and with each other. Product analyses, together with the kinetic data, were used to outline a feasible pathway for the elimination reaction of the compounds under study.
- Al-Awadi, Nouria A.,El-Dusouqui, Osman M. E.,Kaul, Kamini,Dib, Hicham H.
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p. 403 - 407
(2007/10/03)
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- Preparation of 2-isopropylamino pyrimidine
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The invention provides a process for the preparation of 2-isopropylamino-pyrimidine, the process comprising reacting bis(isopropylguanidine)sulphate with 1,1,3,3-tetraethoxy-propane in stoichiometric proportions at 40°-60° C., in acidic aqueous solution.
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