- Synthesis of 1-benzyl-8,9-dihydroimidazo[4,5-c]pyrrolo[3,2-g]quinolin-4(5H) -one via palladium-catalyzed intramolecular arylation
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The synthesis of a novel tetracyclic structure, 8,9-dihydroimidazo[4,5-c] pyrrolo[3,2-g]quinolin-4(5H)-one, has been achieved by a convergent pathway. Coupling of the weakly nucleophilic hindered aromatic amine with 1-benzylimidazole-4-carboxylic acid, 7, afforded the corresponding amide 9 using a DCP/DMF complex; subsequent Heck-type arylation leading to desired tetracyclic molecule imidazo[4,5-c]-pyrrolo[3,2-g]quinolin-4(5H)-one.
- Delest, Bruno,Tisserand, Jean-Yves,Robert, Jean-Michel,Nourrisson, Marie-Renée,Pinson, Patricia,Duflos, Muriel,Le Baut, Guillaume,Renard, Pierre,Pfeiffer, Bruno
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p. 6079 - 6083
(2007/10/03)
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- 1-ALKYL- AND 1-GLUCOSYL-4,5-IMIDAZOLEDICARBOXAMIDES
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Among 4,5-imidazoledicarboxamides compounds were found which possess clearly defined neurotropic activity.In order to study the relation between the structure and the activity a series a new 4,5-imidazoledicarboxamides substituted in the amide groups and at the nitrogen of the imidazole ring were obtained.Their syntheses and characteristics are described.
- Aleksandrova, I. Ya.,Khrustaleva, V. S.,Khromov-Borisov, N. V.
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p. 364 - 367
(2007/10/02)
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