Gibbilimbols A-D (1-4) were synthesized in 32-49% yield over four steps from commercially available starting materials. A copper-catalyzed coupling of 4-methoxyphenylmagnesium bromide with various unsaturated alkyl bromides was the key step in assembling the (long-chain alkyl)-phenol skeleton.
Vyvyan, James R.,Holst, Christian L.,Johnson, Allison J.,Schwenk, Cheryl M.