424800-71-5

Basic information

• Product Name: Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-2,2-dimethyl- (9CI)
• Synonyms: Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-2,2-dimethyl- (9CI);2,2-DIMETHYL-1,4-DIHYDROPYRIDO[2,3-B]PYRAZIN-3(2H)-ONE
• CAS NO: 424800-71-5
• Molecular Formula: C9H11N3O
• Molecular Weight: 177.20314
• Product Categories: PIPERIDINE
• Mol File: 424800-71-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-2,2-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-2,2-dimethyl- (9CI)(424800-71-5)
• EPA Substance Registry System: Pyrido[2,3-b]pyrazin-3(2H)-one, 1,4-dihydro-2,2-dimethyl- (9CI)(424800-71-5)

Safety Data

• Hazardous Substances Data: 424800-71-5(Hazardous Substances Data)

Upstream product

• 424799-90-6 3-nitro-N-(2-methyl-1-propen-1-yl)-2-pyridinamine 
• 452-58-4 2,3-Diaminopyridine 
• 57-15-8 1,1,1-trichloro-2-methyl-2-propanol 
• 104830-06-0 3-iodo-2-aminopyridine 
• 62-57-7 2-Aminoisobutyric acid 
• 13534-99-1 2-Amino-3-bromopyridine 

Relevant articles and documents

Practical synthesis of 3,3-substituted dihydroquinoxalin-2-ones from aryl 1,2-diamines using the Bargellini reaction

The reaction of aromatic 1,2-diamines with trichloromethylcarbinols under mild, basic phase-transfer conditions provided expedient access to 3,3-disubsituted quinoxalin-2(1H)-ones in good to moderate yields. The use of unsymmetrical aryl diamines gave a r

QUINOXALINE DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR

The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.

Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β

Traditional fragment-based drug discovery (FBDD) relies heavily on structural analysis of the hits bound to their targets. Herein, we present a complementary approach based on diversity-oriented synthesis (DOS). A DOS-based fragment collection was able to produce initial hit compounds against the target GSK3β, allow the systematic synthesis of related fragment analogues to explore fragment-level structure-activity relationship, and finally lead to the synthesis of a more potent compound.

Palladium-catalyzed synthesis of quinoxaline derivatives

A palladium-catalyzed reductive N-heteroannulation of enamines derived from 2-nitrobenzenamines forming mixtures of 1,2-dihydroquinoxalines and 3,4-dihydroquinoxalin-2-ones is described. The reactions are performed using bis(dibenzylideneacetone)palladium(0), 1,3-bis(diphenylphosphino)propane, and 1,10-phenanthroline in DMF under 6 atm of carbon monoxide at 70 °C.

A novel palladium-catalyzed synthesis of 1,2-dihydroquinoxalines and 3,4-dihydroquinoxalinones.

Reactions of enamines, derived from 2-nitroanilines and alpha-substituted aldehydes, with carbon monoxide (6 atm) in the presence of a catalytic amount of bis(dibenzylideneacetone)palladium(0) (Pd(dba)(2)) and 1,3-bis(diphenylphosphino)propane (dppp) affo