A pyridazine series of α2/α3 subtype selective GABAA agonists for the treatment of anxiety
The development of a series of GABAA α2/α3 subtype selective pyridazine based benzodiazepine site agonists as anxiolytic agents with reduced sedative/ataxic potential is described, including the discovery of 16, a remarkably α3-selective compou
Lewis, Richard T.,Blackaby, Wesley P.,Blackburn, Timothy,Jennings, Andrew S. R.,Pike, Andrew,Wilson, Rowan A.,Hallett, David J.,Cook, Susan M.,Ferris, Pushpinder,Marshall, George R.,Reynolds, David S.,Sheppard, Wayne F. A.,Smith, Alison J.,Sohal, Bindi,Stanley, Joanna,Tye, Spencer J.,Wafford, Keith A.,Atack, John R.
p. 2600 - 2610
(2007/10/03)
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