425394-84-9

Basic information

• Product Name: Butanoic acid, 4,4-difluoro-2-methyl-3-oxo-, ethyl ester
• Synonyms: Butanoic acid, 4,4-difluoro-2-methyl-3-oxo-, ethyl ester
• CAS NO: 425394-84-9
• Molecular Formula: C7H10F2O3
• Molecular Weight: 180.15
• Mol File: 425394-84-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Butanoic acid, 4,4-difluoro-2-methyl-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4,4-difluoro-2-methyl-3-oxo-, ethyl ester(425394-84-9)
• EPA Substance Registry System: Butanoic acid, 4,4-difluoro-2-methyl-3-oxo-, ethyl ester(425394-84-9)

Safety Data

• Hazardous Substances Data: 425394-84-9(Hazardous Substances Data)

Upstream product

• 454-31-9 ethyl difluoroacetate 
• 105-37-3 Ethyl propionate 

Relevant articles and documents

SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS

Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Preparation of fluorine-containing methyl or aryl alkyl ketone method

The invention discloses a method for preparing fluorine-containing methyl or alkylaryl ketones, belonging to an organic synthesis field. The method comprises two steps of: ester condensation: ester condensation reaction of an R1COOR2 compound represented by a formula A with a R2COOR2 compound represented by a formula B, is performed to form an R1COCH(R3)COOR2 intermediate represented by a formula C; and ester interchange: R1COCH(R3)COOR2 represented by the formula C is carried out ester interchange reaction with R2COOH under 100-110 DEG C and with catalysis of dilute H2SO4 or a cationic resin, and then decarboxylating to obtain R1COR2 fluorine-containing methyl or alkylaryl ketones represented by a formula D. The R1 group may be CF3-, CF2-, CF- or Ar-; the R2 group may be CH3-, Et- and n-Pr; and the R3 group may be CH3-, Et- and H-. Ester interchange in the invention avoids formation of HOR2 which has a nearly same boiling point with the compound represented by the formula D and is azeotropic with the compound represented by the formula D, enables the compound represented by the formula D to be purified without series rectification operation, and is suitable for large scale production. Simultaneously, ester interchange in the invention greatly raises cost. An ion exchange resin completes ester interchange in a waterless condition, which avoids a de-watering step, and simplifies technologies.