426215-05-6Relevant articles and documents
Preparation method of amide
-
Paragraph 0086-0091, (2021/08/25)
The invention relates to a preparation method of an amide, wherein, under the action of oxygen, the isothiocyanate and the aldehyde can react to form an amide, and the reaction temperature can be effectively increased only when not less than 110 °C. This process is also suitable for the reaction of isocyanates with aldehydes to produce amides. The preparation method is cheap in raw material, wide in substrate application range and free of metal catalysts in the reaction process. The initiator or other activator is green and economical, and can effectively reduce the cost.
Iron-Catalyzed Oxidative Coupling Reaction of Isocyanides and Simple Alkanes towards Amide Synthesis
Yuan, Hongdong,Liu, Zhiqiang,Shen, Yushu,Zhao, Hongbin,Li, Chunju,Jia, Xueshun,Li, Jian
supporting information, p. 2009 - 2013 (2019/03/21)
An iron-catalyzed oxidative coupling reaction of isocyanide and readily available alkane has been disclosed. In the presence of a catalytic amount of FeCp2 (10 mol%), heating a mixture of alkane, isocyanide, and DTBP in DCE allows for the formation of an amide. This reaction tolerates many simple alkanes including cycloalkanes and chain alkanes. Furthermore, a series of aromatic isocyanides having different substituents on the aromatic ring are also proven to be effective reaction components. Unfortunately, the employment of aliphatic isocyanides fails to afford the desired products. The present strategy avoids tedious procedures and the employment of toxic starting materials, thus providing an environmentally benign and efficient protocol towards amide synthesis. (Figure presented.).
