Welcome to LookChem.com Sign In|Join Free

CAS

  • or

426219-53-6

TAK-700, also known as orteronel, is a chemical compound that belongs to the class of 17,20-lyase inhibitors. It functions by inhibiting the enzyme 17,20-lyase, which plays a crucial role in the synthesis of androgens like testosterone and dihydrotestosterone. This mechanism of action makes TAK-700 a potential therapeutic agent for hormone-sensitive cancers, particularly prostate cancer, where the reduction of androgen levels can contribute to the decelerated growth of tumors. Additionally, it has shown promise in the treatment of breast cancer in early clinical trials, although further research is necessary to confirm its safety and efficacy in various applications.

426219-53-6 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 426219-53-6 Structure

  • Basic information

    1. Product Name: TAK-700
    2. Synonyms: TAK-700;(2S,3S)-2,3-Dihydroxy-4-oxo-4-(phenylamino)butanoic acid compd. with 6-(6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthalenecarboxamide;TAK-700 (salt);Orteronel (TAK-700)
    3. CAS NO:426219-53-6
    4. Molecular Formula: C18H17N3O2.C10H11NO5
    5. Molecular Weight: 307.3465
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 426219-53-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 685.137 °C at 760 mmHg
    3. Flash Point: 368.157 °C
    4. Appearance: /
    5. Density: 1.351 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: TAK-700(CAS DataBase Reference)
    10. NIST Chemistry Reference: TAK-700(426219-53-6)
    11. EPA Substance Registry System: TAK-700(426219-53-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 426219-53-6(Hazardous Substances Data)

426219-53-6 Usage

Uses

Used in Oncology:
TAK-700 is used as a therapeutic agent for hormone-sensitive cancers, primarily targeting prostate cancer. It works by inhibiting the enzyme 17,20-lyase, thereby reducing the levels of androgens that fuel tumor growth.
Used in Prostate Cancer Treatment:
In the field of prostate cancer treatment, TAK-700 is utilized as an androgen synthesis inhibitor to slow down the progression of the disease by limiting the availability of androgens that promote tumor growth.
Used in Breast Cancer Research:
TAK-700 has also been explored in the context of breast cancer treatment, where it has demonstrated potential benefits in early clinical trials. Its use in this area is aimed at further investigation to understand its full therapeutic potential and safety profile.

Check Digit Verification of cas no

The CAS Registry Mumber 426219-53-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,6,2,1 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 426219-53:
(8*4)+(7*2)+(6*6)+(5*2)+(4*1)+(3*9)+(2*5)+(1*3)=136
136 % 10 = 6
So 426219-53-6 is a valid CAS Registry Number.

426219-53-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3S)-4-anilino-2,3-dihydroxy-4-oxobutanoic acid, 6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methylnaphthalene-2-carboxamide

1.2 Other means of identification

Product number -
Other names CS-0421

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:426219-53-6 SDS

426219-53-6Downstream Products

426219-53-6Relevant articles and documents

1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4

Ruchelman, Alexander L.,Man, Hon-Wah,Chen, Roger,Liu, Wei,Lu, Ling,Cedzik, Dorota,Zhang, Ling,Leisten, Jim,Collette, Alice,Narla, Rama Krishna,Raymon, Heather K.,Muller, George W.

, p. 6356 - 6374 (2011)

A series of 1,1-diarylalkene derivatives were prepared to optimize the properties of CC-5079 (1), a dual inhibitor of tubulin polymerization and phosphodiesterase 4 (PDE4). By using the 3-ethoxy-4-methoxyphenyl PDE4 pharmacophore as one of the aromatic ri

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 426219-53-6