426226-10-0Relevant articles and documents
Regulation of type 5 adenylyl cyclase for treatment of neurodegenerative and cardiac diseases
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Page/Page column 33, (2010/11/24)
The invention concerns pharmaceutical compositions that contain a compound or compounds that can effectively regulate the activity of Type 5 Adenylyl Cyclase and methods for treatment of neurological diseases and disorders, as well as motor function loss
Metal coordination-based inhibitors of adenylyl cyclase: Novel potent P-site antagonists
Levy, Daniel E.,Bao, Ming,Cherbavaz James, Diana B.,Tomlinson,Sedlock, David M.,Homcy, Charles J.,Scarborough, Robert M.
, p. 2177 - 2186 (2007/10/03)
The adenylyl cyclases (ACs) are a family of intracellular enzymes associated with signal transduction by virtue of their ability to convert ATP to cAMP. The catalytic mechanism of this transformation proceeds through initial binding of ATP to the so-calle