4269-30-1

Basic information

• Product Name: 3-(PIPERIDIN-1-YL)PROPANAMIDE
• Synonyms: 3-(PIPERIDIN-1-YL)PROPANAMIDE
• CAS NO: 4269-30-1
• Molecular Formula: C8H16N2O
• Molecular Weight: 156.23
• Mol File: 4269-30-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(PIPERIDIN-1-YL)PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(PIPERIDIN-1-YL)PROPANAMIDE(4269-30-1)
• EPA Substance Registry System: 3-(PIPERIDIN-1-YL)PROPANAMIDE(4269-30-1)

Safety Data

• Hazardous Substances Data: 4269-30-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(PIPERIDIN-1-YL)PROPANAMIDE is used as a key intermediate for the synthesis of various pharmaceuticals, leveraging its structural properties to contribute to the development of new medications. Its presence in the synthesis process aids in the creation of compounds that can address a range of health conditions.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 3-(PIPERIDIN-1-YL)PROPANAMIDE is utilized as a valuable component in research. It is instrumental in studying the effects of different molecular structures on the activity and efficacy of potential drugs, thereby playing a crucial role in advancing our understanding of drug mechanisms.
Used in Organic Compounds Synthesis:
3-(PIPERIDIN-1-YL)PROPANAMIDE also serves as a fundamental building block in the synthesis of a variety of organic compounds. Its unique structure allows for the formation of complex molecules that can be applied across different industries, including but not limited to the chemical and materials science sectors.
Used in Drug Development:
3-(PIPERIDIN-1-YL)PROPANAMIDE is used as a precursor in drug development, where its analgesic and neuroprotective properties are harnessed to formulate medications aimed at treating pain and protecting the nervous system. This makes it an essential part of the pipeline for creating new therapeutic agents.
Overall, 3-(PIPERIDIN-1-YL)PROPANAMIDE is a versatile chemical entity with applications that span across the pharmaceutical and chemical industries, making significant contributions to the development of new drugs and organic compounds.

Upstream product

• 110-89-4 piperidine 
• 79-06-1 2-propenamide 
• 6320-96-3 3-bromopropanamide 

Relevant articles and documents

Understanding water mediated proton migration in conversion of π-bond in olefinic carbon atoms into C–N bond to form β-amino adducts

The aza-Michael reactions with a variety of substrates were conducted in water affording the quantitative yields without any external catalyst, which is contrary to that published in literature. A more rational approach to analyze this problem was by conducting this conspicuous reaction with a variety of substrates in water and the results were analyzed using advanced theoretical calculations. Our investigation on the role of water in the reaction proposed a mechanism wherein water plays dual role both as medium as well as catalyst to facilitate the C–N bond formation using powerful tool in its armory, the “H-bonding”. Reactions were conducted in the absence of an external catalyst or co-solvents and, hence, are a greener approach in organic synthesis. The reactions of 15 examples were conducted with a variety of substrates to afford the addition products in the range of 70–95% yield. Theoretical studies on the transition state analysis suggested that it was the assistance of water, through H-bonding, that facilitated the conjugate addition of amine and proton transfer from ammonium ion, which could happen through two equally possible pathways.

On-water magnetic NiFe2O4 nanoparticle-catalyzed Michael additions of active methylene compounds, aromatic/aliphatic amines, alcohols and thiols to conjugated alkenes

Here, we have demonstrated the Michael addition of active methylene compounds, aromatic/aliphatic amines, thiols and alcohols to conjugated alkenes using magnetic nano-NiFe2O4 as reusable catalyst in water. Nano-NiFe2O4 efficiently catalyzed the formation of C-C and C-X (X = N, S, O etc.) bond through 1,4-addition reactions.

Dolomite (CaMg(CO3)2) as a recyclable natural catalyst in Henry, Knoevenagel, and Michael reactions

Iranian dolomite (CaMg(CO3)2) which consists of double-layered carbonates with Ca2+ and Mg2+ ions was utilized as a heterogeneous base catalyst in the CC, CN, and CS bond forming reactions via the Henry, Knoevenagel, aza-Michael, and thia-Michael transformations under mild conditions in water. Iranian dolomite has been characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Brunauer Emmett Teller (BET) and XRF chemical analysis, while its basic strength was evaluated by following the Hammett indicators procedure. This water-insoluble natural catalyst demonstrated high activity and was reusable.

Accelerated C-N bond formation in dropcast thin films on ambient surfaces

The aza-Michael addition and the Mannich condensation occur in thin films deposited on ambient surfaces. The reagents for both C-N bond formation reactions were transferred onto the surface by drop-casting using a micropipette. The surface reactions were

Graphene oxide: An efficient and reusable carbocatalyst for aza-Michael addition of amines to activated alkenes

Graphene oxide was found to be a highly efficient, reusable and cost-effective organocatalyst for the aza-Michael addition of amines to activated alkenes to furnish corresponding β-amino compounds in excellent yields. The Royal Society of Chemistry 2011.

An efficient biomaterial supported bifunctional organocatalyst (ES-SO 3- C5H5NH+) for the synthesis of β-amino carbonyls

A biomaterial supported organocatalyst, readily synthesized by the reaction of chemically modified sulfonic group containing expanded corn starch with pyridine exhibited excellent catalytic activity for the synthesis of β-amino carbonyls in excellent yields via aza-Michael addition of amines to electron deficient alkenes. A remarkable enhancement in the reaction rates was observed with the prepared bifunctional organocatalyst in comparison to the either starch grafted sulfonic acid or the corresponding homogeneous pyridinium p-toluenesulfonate.

Silicon tetrachloride catalyzed aza-michael addition of amines to conjugated alkenes under solvent-free conditions

The efficient and very simple conjugate addition of aromatic and aliphatic amines to α,β-unsaturated carbonyl compounds under solvent-free conditions in the presence of catalytic amount of silicon tetrachloride is reported. The reaction of aryl and alkyl amines with different Michael acceptors gave the corresponding Michael adducts with simple catalyst and good to excellent yields. Georg Thieme Verlag Stuttgart New York.

Microwave-assisted, rapid, solvent-free aza-michael reaction by perchloric acid impregnated on silica gel

Highly efficient solvent-free aza-Michael additions of a variety of amines to,-unsaturated carbonyl compounds under microwave-irradiation conditions catalyzed by perchloric acid impregnated on silica gel (HClO4/SiO2) is reported. The reactions are completed within 2-7min in a microwave oven to produce the corresponding adducts in excellent yields, and the catalyst can be recovered and reused.

SUBSTITUTED PYRROLIDINE AND PIPERIDINE COMPOUNDS, DERIVATIVES THEREOF, AND METHODS FOR TREATING PAIN

The present application relates to pyrrolidine, piperidine, and other nitrogen-containing heterocyclic derivatives and the use of these compounds for treating and preventing pam or inflammation. The analgesic compounds demonstrate efficacy in the treatment of neuropathic pain resulting from a variety of conditions such as diabetic neuropathy, HIV infections, and post-herpetic neuralgia.

Silica gel accelerated aza-Michael addition of amines to α,β-unsaturated amides

A novel method to synthesize β-amino amide has been developed via conjugated addition of amine to bulky α,β-unsaturated amides promoted by silica gel. The silica gel worked efficiently to accelerate the reaction and afforded the related adduct in good to excellent yield.