- Redox-Neutral Imination of Alcohol with Azide: A Sustainable Alternative to the Staudinger/Aza-Wittig Reaction
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The traditional Staudinger/aza-Wittig reaction represents one of the most powerful tools for imine formation. However, for this multistep procedure, the sacrificial phosphine has to be used, resulting in difficulties in the purification process and waste disposal at the same time. Here, we report a redox-neutral azide-alcohol imination methodology enabled by a base-metal nickel PN3 pincer catalyst. The one-step, waste-free, and high atom-economical features highlight its advantages further. Moreover, mechanistic insight suggests a non-metal-ligand cooperation pathway based on the observation of an intermediate and density functional theory calculations.
- Li, Huaifeng,Lupp, Daniel,Das, Pradip K.,Yang, Li,Gon?alves, Théo P.,Huang, Mei-Hui,El Hajoui, Marwa,Liang, Lan-Chang,Huang, Kuo-Wei
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p. 4071 - 4076
(2021/04/12)
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- Tandem imine formationviaauto-hydrogen transfer from alcohols to nitro compounds catalyzed by a nanomagnetically recyclable copper catalyst under solvent-free conditions
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A direct imination reaction was developed by tandem reaction of alcohols and nitro compounds in the presence of Cu-isatin Schiff base-γ-Fe2O3as a nanomagnetically recyclable catalyst under solvent-free conditions. By this method, various imines were prepared in good to high yields from one-pot reaction of various alcohols (primary aromatic and aliphatic) and nitro compounds (aromatic and aliphatic)viaan auto-hydrogen transfer reaction. Use of an inexpensive and easily reusable catalyst, without requiring any additives or excess amounts of benzyl alcohol as the reaction solvent are the other advantages of this method. This catalytic system has the merits of cost effectiveness, environmental benignity, excellent recyclability and good reproducibility.
- Derakhshan, Seyed Ruhollah,Hosseini Moghadam, Hadis,Sansano, José Miguel,Sobhani, Sara
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p. 19121 - 19127
(2021/06/03)
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- Photocatalytic one-pot multidirectional N-alkylation over Pt/D-TiO2/Ti3C2: Ti3C2-based short-range directional charge transmission
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Visible-light-induced one-pot, multistep, and chemoselectivity adjustable reactions highlight the economical, sustainable, and green process. Herein, we report Pt nanoparticles dispersed on S and N co-doped titanium dioxide/titanium carbide (MXene) (3%Pt/
- Jiang, Heyan,Sheng, Meilin,Li, Yue,Kong, Shuzhen,Bian, Fengxia
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- Biorenewable carbon-supported Ru catalyst for: N -alkylation of amines with alcohols and selective hydrogenation of nitroarenes
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Herein, we developed a renewable carbon-supported Ru catalyst (Ru/PNC-700), which was facilely prepared via simple impregnation followed by the pyrolysis process. The prepared Ru/PNC-700 catalyst demonstrated remarkable catalytic activity in terms of conversion and selectivity towards N-alkylation of anilines with benzyl alcohol and chemoselective hydrogenation of aromatic nitro compounds. In addition, local anesthetic pharmaceutical agents (e.g., butamben and benzocaine), including key drug intermediates, were synthesized in excellent yields under mild conditions and in the presence of water as a green solvent. Moreover, the prepared Ru/PNC-700 catalyst could be easily recovered and reused up to five times without any apparent loss in activity and selectivity.
- Goyal, Vishakha,Narani, Anand,Natte, Kishore,Poddar, Mukesh Kumar,Ray, Anjan,Sarki, Naina,Tripathi, Deependra
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p. 14687 - 14694
(2021/08/23)
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- Catalyst- And solvent-free efficient access to: N -alkylated amines via reductive amination using HBpin
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A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and is compatible with a wide range of sterically and electronically diverse aldehydes and primary amines. Notably, this simple process offers scalability, excellent functional group tolerance, chemoselectivity, and is also effective at the synthesis of biologically relevant molecules. This journal is
- Bauri, Somnath,Pandey, Vipin K.,Rit, Arnab
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supporting information
p. 3853 - 3857
(2020/07/27)
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- Ultrasound-assisted construction of a Z-scheme heterojunction with g-C3N4 nanosheets and flower-like Bi2WO6 microspheres and the photocatalytic activity in the coupling reaction between alcohols and amines under visible light irradiation
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Flower-like Bi2WO6 microspheres and bulk g-C3N4 were prepared by the hydrothermal method and high-temperature calcining method, respectively. A new method based on the combination of ultrasonic stripping and mechanical stirring was used to obtain uniform composite x-Bi2WO6/g-C3N4 (x is the Bi2WO6 mass ratio) photocatalysts with a Z-scheme heterojunction. In the reaction of benzyl alcohol and aniline to form imine, the optimal composite, 30percent-Bi2WO6/g-C3N4, showed a conversion rate of 87.6percent, which is much higher than that of pure Bi2WO6 and g-C3N4. Characterization by SEM and TEM showed that the ultrasonically stripped g-C3N4 significantly reduced the radial dimension compared to bulk g-C3N4. A uniformly dispersed photocatalytic material was formed, and it maintained a flower-like microsphere structure. Materials characterized by N2 adsorption–desorption isotherms (BET) showed that the specific surface area of the g-C3N4 nanosheets increased by approximately ten times after ultrasonic stripping. The photostability of the composite was verified by cyclic experiments. Under visible light irradiation, the activation energy of the coupling reaction between benzyl alcohol and aniline was found to be decreased by 29.8 kJ mol?1. A capture experiment was used to verify the active species in the photocatalytic system, with the reaction found to be mainly completed through the synergistic action of h+, e? and ?O2?.
- Hao, Xueli,Li, Enbo,Li, Haiying,Li, Jingyi,Wang, Yan,Wang, Zhibao,Yu, Xiujuan,Zhang, Zhiying
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- Switching the N-Alkylation of Arylamines with Benzyl Alcohols to Imine Formation Enables the One-Pot Synthesis of Enantioenriched α-N-Alkylaminophosphonates
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The selective N-alkylation of anilines with benzylic alcohols can be switched in favor of the dehydrogenative condensation process using the nitrile-ligated Kn?lker's complex by conducting the reaction either in a closed system under inert conditions, or in an open system in air. The selective formation of imines, containing reactive C=N bonds, provides an opportunity towards further functionalization. Indeed, a one-pot three-component condensation of alcohols, amines and phosphites, promoted by an iron-based Kn?lker-type complex in combination with a chiral BINOL-based phosphoric acid, provides access to enantioenriched α-N-alkylaminophosphonates.
- Hofmann, Natalie,Hultzsch, Kai C.
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supporting information
p. 3105 - 3111
(2019/06/08)
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- Readily Available Primary Aminoboranes as Powerful Reagents for Aldimine Synthesis
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Primary aminoboranes (RNHBR2), which are readily available by spontaneous dehydrocoupling of amines and boranes cleanly react at room temperature with aldehydes to give aldimines. The overall transformation from amines to aldimines can be conveniently performed by a sequential one-pot reaction. This synthetic strategy is especially useful for electron poor and bulky amines which are reluctant to react with aldehydes under dehydration conditions. Using a Glorius robustness screen, we show that this methodology is chemoselective, and functional group tolerant. Computational and experimental data support the irreversible formation of the aldimine product in marked contrast with traditional methods.
- Junor, Glen P.,Romero, Erik A.,Chen, Xi,Jazzar, Rodolphe,Bertrand, Guy
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supporting information
p. 2875 - 2878
(2019/02/13)
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- The preparation and photocatalytic activity of Ag-Pd/g-C3N4 for the coupling reaction between benzyl alcohol and aniline
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In this study, the carrier g-C3N4 was prepared by melamine, and the Ag-Pd/g-C3N4 catalyst was synthesized by the NaBH4 reduction method. Different characterization techniques, including SEM, TEM, XRD, UV–vis DRS, XPS, photoluminescence spectra (PL) and BET, were employed to investigate the morphology and optical properties of the as-prepared samples. The Ag-Pd/g-C3N4 catalyst was used for the synthesis of imine from a benzyl alcohol and aniline. The results show that when the total loading of Ag and Pd is 2 wt%, and the mass ratio of Ag and Pd is 1:1, the activity of the catalyst is the highest (The highest conversion of aniline is 86.7% and the product selectivity is >99%.). The reaction is optimized by changing the type of solvent, the type and amount of base, the type of catalyst, and the amount of reactants. The optimal reaction conditions are 6 ml of n-hexane, 1.4 mmol of Cs2CO3, 50 mg of the Ag-Pd/g-C3N4 (2 wt%, 1:1), and 2:1 mol ratio of benzyl alcohol and aniline. Under optimal reaction conditions, alcohol derivatives and amine derivatives were investigated to determine the suitable range of the catalyst for alcohols and amines. Then, the effects of different light intensities and wavelengths on the reaction were explored. Additionally, the catalyst's recycling ability was tested, and it was found to be relatively stable. The effect of reactive groups on the mechanism shows that the reaction is mainly achieved by the synergy between h+, e? and ·O2?.
- Ma, Jingjing,Yu, Xiujuan,Liu, Xiaoling,Li, Haiying,Hao,Li, Jingyi
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- Tert-Butyl Nitrite Promoted Oxidative Intermolecular Sulfonamination of Alkynes to Synthesize Substituted Sulfonyl Pyrroles from the Alkynylamines and Sulfinic Acids
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tert-Butyl nitrite promoted oxidative intermolecular sulfonamination of alkynes to synthesize substituted sulfonyl pyrroles from the alkynylamines and sulfinic acids via tandem addition/cyclization was developed. This reaction is performed well by employing tert-butyl nitrite as the oxidant, and various substituted sulfonyl pyrroles are formed in moderate to good yields with no requirement of metal catalysis.
- Qi, Zhenjie,Jiang, Yong,Wang, Yanyan,Yan, Rulong
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supporting information
p. 8636 - 8644
(2018/06/18)
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- PdAu@MIL-100(Fe) cooperatively catalyze tandem reactions between amines and alcohols for efficient N-alkyl amines syntheses under visible light
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PdAu@MIL-100(Fe), with PdAu alloy nanoparticles of ca. 1.7 nm encapsulated inside MIL-100(Fe) cavities, were prepared via a double-solvent impregnation followed by photoreduction. As compared with bare Pd@MIL-100(Fe), bimetallic PdAu@MIL-100(Fe) showed superior activities for the tandem reactions between amines and alcohols to produce N-alkyl amines under visible-light irradiation, ascribed to the promoting effect of metallic Au in the photocatalytic alcohol-to-aldehyde dehydrogenation. A Pd/Au ratio dependent N-alkylation activity was observed over PdAu@MIL-100(Fe), implying the possibility of synchronizing the reaction rates of two consecutive steps in the N-alkylation reaction, i.e., photocatalytic alcohol-to-aldehyde dehydrogenation and imines hydrogenation, to optimize the whole reaction. This study provides a highly efficient and stable catalytic system for the realization of alkylation of amines via a successful coupling of MOF-based photocatalysis and metal nanoparticle-based hydrogenation. This work also demonstrates that the reaction rates of different catalytic steps in a cascade/tandem reaction can be synchronized for an efficient overall reaction via a rational design of the multifunctional catalysts.
- Wang, Dengke,Pan, Yating,Xu, Lizhi,Li, Zhaohui
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p. 248 - 254
(2018/04/02)
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- Preparation method for imine
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The invention provides a preparation method for imine. The preparation method comprises the following steps: adding an aromatic nitro compound and an alcohol compound into a reaction vessel as substrates; then adding a solvent and a molybdenum sulfide-based catalyst; introducing inert gas to replace an atmosphere in the reaction vessel for synthesis; enclosing the reaction vessel; carrying out stirring and a heating reaction; after completion of the reaction, carrying out centrifugation to remove the catalyst; evaporating the solvent; and carrying out column separation and purification so as to obtain a product, i.e., an imine compound. The method provided by the invention prepares imine through coupling with the cheap and easily available alcohol compound and the aromatic nitro compound as the substrates; under the action of different polyphase molybdenum sulfide-based catalysts, a high conversion rate and high imine selectivity are obtained; and the method uses an atom-economic reaction, and no alkali additive is needed in the reaction.
- -
-
Paragraph 0063-0066; 0067-0105; 0110; 0111; 0115-0120
(2017/05/23)
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- Synthetic method of imine
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The invention relates to a method for preparing imine from an azo compound and an alcohol compound through hydrogen transition coupling. The method specifically comprises: dispersing and dissolving an azo compound and an alcohol compound which are taken as substrates in an organic solvent, adding a nickel-based catalyst, putting the obtained mixture in a synthesis kettle, leading inert gas in to replace internal air, performing sealing and stirring, carrying out a heating reaction, performing centrifugation to remove the catalyst after the reaction is over, performing rotary evaporation to remove the solvent, and performing purification through recrystallization to obtain the sample. In the catalytic action of different multi-phase nickel-based catalysts, the reaction is high in conversion rate and imine selectivity. The method is an atom economic reaction.
- -
-
Paragraph 0079; 0080
(2017/06/02)
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- A Powerful Chiral Phosphoric Acid Catalyst for Enantioselective Mukaiyama–Mannich Reactions
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A new BINOL-derived chiral phosphoric acid bearing 2,4,6-trimethyl-3,5-dinitrophenyl substituents at the 3,3′-positions was developed. The utility of this chiral phosphoric acid is demonstrated by a highly enantioselective (ee up to >99 %) and diastereoselective (syn/anti up to >99:1) asymmetric Mukaiyama–Mannich reaction of imines with a wide range of ketene silyl acetals. Moreover, this method was successfully applied to the construction of vicinal tertiary and quaternary stereogenic centers with excellent diastereo- and enantioselectivity. Significantly, BINOL-derived N-triflyl phosphoramide constitutes a complementary catalyst system that allows the title reaction to be applied to more challenging imines without an N-(2-hydroxyphenyl) moiety.
- Zhou, Fengtao,Yamamoto, Hisashi
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p. 8970 - 8974
(2016/07/26)
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- Synthesis and Characterization of Iron-Nitrogen-Doped Graphene/Core-Shell Catalysts: Efficient Oxidative Dehydrogenation of N-Heterocycles
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An important goal for nanocatalysis is the development of flexible and efficient methods for preparing active and stable core-shell catalysts. In this respect, we present the synthesis and characterization of iron oxides surrounded by nitrogen-doped-graphene shells immobilized on carbon support (labeled FeOx@NGr-C). Active catalytic materials are obtained in a simple, scalable and two-step method via pyrolysis of iron acetate and phenanthroline and subsequent selective leaching. The optimized FeOx@NGr-C catalyst showed high activity in oxidative dehydrogenations of several N-heterocycles. The utility of this benign methodology is demonstrated by the synthesis of pharmaceutically relevant quinolines. In addition, mechanistic studies prove that the reaction progresses via superoxide radical anions (·O2-).
- Cui, Xinjiang,Li, Yuehui,Bachmann, Stephan,Scalone, Michelangelo,Surkus, Annette-Enrica,Junge, Kathrin,Topf, Christoph,Beller, Matthias
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supporting information
p. 10652 - 10658
(2015/09/28)
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- One-pot reductive amination of araldehydes by aniline using borohydride with CeCl3·7H2O as catalyst
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A one-pot, two-step reductive amination of araldehydes or acetophenones with anilines using NaBH4as a cheap hydride source and catalysed by CeCl3·7H2O has been achieved in EtOH at room temperature in good yields.
- Zhu, Xun,Zhou, Xiuqin,Zhang, Wei
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p. 390 - 393
(2015/08/18)
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- A conjugated ketone as a catalyst in alcohol amination reactions under transition-metal and hetero-atom free conditions
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Here, we show the results of a molecular-defined conjugated ketone catalyzed alcohol amination reaction. Under the optimized reaction conditions, the yields to the desired products reached 98%. The reaction mechanism and kinetic study supposed that carbonyl-hydroxyl groups are the catalytically active sites, and the transfer-hydrogenation reactions progress via the recycling of carbonyl and hydroxyl groups. The catalytic process shows promise as an efficient and economic route for alcohol amination reactions.
- Dai, Xingchao,Cui, Xinjiang,Deng, Youquan,Shi, Feng
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p. 43589 - 43593
(2015/05/27)
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- Synthesis of anti-2,3-dihydro-1,2,3-trisubstituted-1H-naphth [1,2-e][1,3]oxazine derivatives via multicomponent approach
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A series of anti-2,3-dihydro-1,2,3-trisubstituted-1H-naphth [1,2-e][1,3]oxazine derivatives 6 were exclusively obtained in high yields for the first time through multicomponent reactions (MCRs) of 2-naphthol, aromatic aldehydes and electron rich primary amines in ethanol at room temperature using CCl3COOH as catalyst. The same reaction could be conducted effectively in solvent-free medium at 100 °C. The stereochemistry of the two hydrogens connected to C-2 and C-4 (1,3) positions of the oxazine ring are identified as anti-orientation by single crystal XRD, COSY and NOESY analysis.
- Borah, Ruli,Dutta, Arup Kumar,Sarma, Parishmita,Dutta, Champak,Sarma, Bipul
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p. 10912 - 10917
(2014/03/21)
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- Use of primary amines for the selective n-alkylation of anilines by a reusable heterogeneous catalyst
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Traditionally, anilines can be alkylated with reactive alkyl halides but now more safe reagents such as alcohols or even amines can be used. To overcome the limits of homogeneous catalysis for aniline N-alkylation, we have developed a protocol that employs simple Pd/C as a heterogeneous catalyst under microwave dielectric heating. The process, based on the easy Pd-mediated oxidation of primary amines to imines followed by aniline addition, is characterized by a high atom economy as ammonia is the only other product of the reaction. This kind of aniline alkylation with amines has been carried out both in ionic liquid medium using [bmim]PF6 or in a more traditional solvent such as THF where the catalyst could be successfully recycled more times. The reusability of the catalyst was further confirmed by using material recycled from the amination in a standard alkene hydrogenation without loss of efficiency. Georg Thieme Verlag Stuttgart New York.
- Linciano, Pasquale,Pizzetti, Marianna,Porcheddu, Andrea,Taddei, Maurizio
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p. 2249 - 2254
(2013/11/06)
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- Mild and efficient PtO2-catalyzed one-pot reductive mono-N-alkylation of nitroarenes
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(Chemical Equation Presented) A mild and efficient one-pot reductive monoalkylation of nitroarenes has been described using aldehydes as alkylating agents, molecular hydrogen as a reducing agent, and PtO2 as a catalyst in methanol. This methodology is found to be applicable for both aliphatic and aromatic aldehydes and for a wide variety of nitroarenes. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Commuications to view the free supplemental file. Copyright Taylor & Francis Group, LLC.
- Sreedhar, Bojja,Rawat, Vikas S.
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experimental part
p. 2490 - 2502
(2012/07/14)
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- Electrochemical allylation reactions of simple imines in aqueous solution mediated by nanoscale zinc architectures
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I zinc we're alone now: The title reactions were achieved in an undivided cell fitted with a pair of zinc electrodes in aqueous solution. A preliminary study on the relationship of reaction activity and surface morphology showed that the deposited zinc powders with nanoscale architectures had very high activity.
- Huang, Jing-Mei,Wang, Xu-Xiao,Dong, Yi
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supporting information; experimental part
p. 924 - 927
(2011/03/20)
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- Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists
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Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M3 muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction. These compounds have also presented a high level of metabolic transformation (human liver microsomes). The synthesis, structure-activity relationships and biological evaluation of these compounds are reported.
- Prat, Maria,Buil, María Antonia,Fernández, Maria Dolors,Castro, Jordi,Monleón, Juan Manuel,Tort, Laia,Casals, Gaspar,Ferrer, Manuel,Huerta, Josep Maria,Espinosa, Snia,López, Manuel,Segarra, Victor,Gavald, Amadeu,Miralpeix, Montserrat,Ramos, Israel,Vilella, Dolors,González, Marisa,Córdoba, Mnica,Cárdenas, Alvaro,Antón, Francisca,Beleta, Jorge,Ryder, Hamish
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scheme or table
p. 3457 - 3461
(2011/06/24)
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- Direct one-pot reductive imination of nitroarenes using aldehydes and carbon monoxide by titania supported gold nanoparticles at room temperature
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The direct one-pot reductive imination of nitroarenes with various aldehydes by a titania supported gold catalyst at room temperature using CO/H2O as a reducing agent is illustrated. This method is simple, economic, general and environmentally benign, thus resulting in practical advantages for the synthesis of imines and their derivatives.
- Huang, Jun,Yu, Lei,He, Lin,Liu, Yong-Mei,Cao, Yong,Fan, Kang-Nian
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supporting information; experimental part
p. 2672 - 2677
(2011/11/06)
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- Polyethylene glycol clicked Co(ii) Schiff base and its catalytic activity for the oxidative dehydrogenation of secondary amines
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Copper catalyzed [3+2] cycloaddition "click method" provided an efficient and high yielding immobilization of cobalt(ii) Schiff base to the azido-functionalized MeOPEG5000; whereas the direct reaction between MeOPEG5000 and Co(ii) Schiff base did not produce any immobilization. The prepared catalyst was tested for the oxidative dehydrogenation of various secondary amines using TBHP as oxidant and could be easily recovered by precipitation with diethyl ether at the end of the reaction.
- Khatri, Praveen K.,Jain, Suman L.,Sivakumar K.,Sain, Bir
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experimental part
p. 3370 - 3374
(2011/06/25)
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- One-pot synthesis of imines from alcohols and amines with TiO2 loading Pt nanoparticles under UV irradiation
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TiO2 loading Pt nanoparticles (Pt@TiO2) promote one-pot synthesis of imines from alcohols and amines under UV irradiation at room temperature. This is achieved via a Pt-assisted photocatalytic oxidation of alcohols and a catalytic condensation of the formed aldehydes with amines on the TiO2 surface. The Royal Society of Chemistry 2011.
- Shiraishi, Yasuhiro,Ikeda, Makoto,Tsukamoto, Daijiro,Tanaka, Shunsuke,Hirai, Takayuki
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supporting information; experimental part
p. 4811 - 4813
(2011/05/15)
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- Synthesis of imines from nitrobenzene and TiO2 particles suspended in alcohols via semiconductor photocatalysis type B
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UV irradiation on a non-aqueous suspension of titanium dioxide with nitrobenzene and different alcohols in deaerated conditions produces imines and aniline as main products. The conversion of nitrobenzene and the corresponding selectivity of imines or aniline depend on the type of alcohol used. A low conversion (3-12%) and selectivity close to 100% to imines were obtained with methyl, ethyl, or propyl alcohol. Otherwise, using i-propanol only aniline was detected with a conversion of 13%. Finally, a mixture of aniline and imines was formed employing n-butyl, n-amyl, and i-amyl alcohols with the higher conversion (~50%).
- Rios-Bern?, Omar,Flores, Sergio O.,Córdova, Iván,Valenzuela, Miguel A.
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experimental part
p. 2730 - 2733
(2010/06/14)
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- One-pot preparation of chiral beta-amino esters by rhodium-catalyzed three-components coupling reaction.
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Chiral beta-amino esters are synthesized in one-pot from three components, amines, aldehydes, and ethyl bromoacetate, under the rhodium-catalyzed Reformatsky-type reaction condition, where complete diastereoselection is achieved in the nucleophilic addition step of ethyl bromoacetate to the imines prepared in
- Honda, Toshio,Wakabayashi, Hitoshi,Kanai, Kazuo
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p. 307 - 308
(2007/10/03)
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- A one-pot aza-Wittig based solution and polymer supported route to amines
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This paper presents a high yielding one-pot solution phase and polymer supported synthesis of a range of primary and secondary amines starting from azides and aldehydes. The synthesis utilises a tandem process which begins with an aza-Wittig reaction between the aldehyde and an iminophosphorane, followed by reduction, or organometallic 1,2-addition reaction, of the resultant imine. The requisite iminophosphoranes were accessed using the highly efficient Staudinger reaction between the azide starting material and a phosphine. The process was applicable to the solid phase by the use of polymer supported iminophosphoranes and polymer supported cyanoborohydride.
- Hemming,Bevan,Loukou,Patel,Renaudeau
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p. 1565 - 1568
(2007/10/03)
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- SYNTHESIS OF ALIPHATIC-AROMATIC AMINES IN THE PRESENCE OF THE COMPLEXES OF PALLADIUM IONS WITH POLYTRIMETHYLOLMELAMINE
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The complexes of palladium ions with polytrimethylolmelamine effectively catalyze the hydrogenation amination of aldehydes with nitrobenzene under mild conditions (1 atm of hydrogen, 18-50 deg C).The intermediate products in the amination of aldehydes with nitro-, azo-, and azoxybenzene are phenylhydroxylamine, aniline, and the corresponding azomethine.
- Klyuev, M. V.
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p. 1741 - 1745
(2007/10/02)
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- ACYLATION OF SCHIFF BASES WITH METHYL CHLOROCARBONATE
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N-Substituted N-alkenylcarbamates are formed in the reaction of Schiff bases, obtained from aldehydes and ketones, with methyl chlorocarbonate in the presence of diethylaniline.
- Mochalin, V. B.,Rogozin, K. I.
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p. 1268 - 1270
(2007/10/02)
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