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CAS

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428856-24-0

3-(1H-BENZOIMIDAZOL-2-YL)-2-METHYL-PHENYLAMINE is a chemical compound with the molecular formula C15H15N3. It is a derivative of benzimidazole and consists of a benzimidazole ring substituted with a methyl-phenylamine group. 3-(1H-BENZOIMIDAZOL-2-YL)-2-METHYL-PHENYLAMINE has potential applications in pharmaceutical research and can be used as a building block in the synthesis of various biologically active compounds. Its structure and properties make it a valuable tool for the development of new drugs and medicinal compounds.

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  • 428856-24-0 Structure

  • Basic information

    1. Product Name: 3-(1H-BENZOIMIDAZOL-2-YL)-2-METHYL-PHENYLAMINE
    2. Synonyms: ASISCHEM T31066;ART-CHEM-BB B025066;3-(1H-BENZOIMIDAZOL-2-YL)-2-METHYL-PHENYLAMINE;3-(1H-BENZIMIDAZOL-2-YL)-2-METHYLANILINE;AKOS BB-7979;TIMTEC-BB SBB007294
    3. CAS NO:428856-24-0
    4. Molecular Formula: C14H13N3
    5. Molecular Weight: 223.27
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 428856-24-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(1H-BENZOIMIDAZOL-2-YL)-2-METHYL-PHENYLAMINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(1H-BENZOIMIDAZOL-2-YL)-2-METHYL-PHENYLAMINE(428856-24-0)
    11. EPA Substance Registry System: 3-(1H-BENZOIMIDAZOL-2-YL)-2-METHYL-PHENYLAMINE(428856-24-0)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 428856-24-0(Hazardous Substances Data)

428856-24-0 Usage

Uses

Used in Pharmaceutical Research:
3-(1H-BENZOIMIDAZOL-2-YL)-2-METHYL-PHENYLAMINE is used as a building block for the synthesis of biologically active compounds, contributing to the development of new drugs and medicinal compounds.
Used in Drug Development:
3-(1H-BENZOIMIDAZOL-2-YL)-2-METHYL-PHENYLAMINE is used as a valuable tool in drug development, aiding in the creation of novel pharmaceuticals with potential therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 428856-24-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,8,8,5 and 6 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 428856-24:
(8*4)+(7*2)+(6*8)+(5*8)+(4*5)+(3*6)+(2*2)+(1*4)=180
180 % 10 = 0
So 428856-24-0 is a valid CAS Registry Number.

428856-24-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(1H-Benzoimidazol-2-yl)-2-methyl-phenylamine

1.2 Other means of identification

Product number -
Other names 3-(1H-benzimidazol-2-yl)-2-methylaniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:428856-24-0 SDS

428856-24-0Downstream Products

428856-24-0Relevant articles and documents

Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae

Keurulainen, Leena,Salin, Olli,Siiskonen, Antti,Kern, Jan Marco,Alvesalo, Joni,Kiuru, Paula,Maass, Matthias,Yli-Kauhaluoma, Jari,Vuorela, Pia

, p. 7664 - 7674 (2011/03/17)

Chlamydia pneumoniae is an intracellular bacterium that responds poorly to antibiotic treatment. Insufficient antibiotic usage leads to chronic infection, which is linked to disease processes of asthma, atherosclerosis, and Alzheimer's disease. The Chlamydia research lacks genetic tools exploited by other antimicrobial research, and thus other approaches to drug discovery must be applied. A set of 2-arylbenzimidazoles was designed based on our earlier findings, and 33 derivatives were synthesized. Derivatives were assayed against C. pneumoniae strain CWL-029 in an acute infection model using TR-FIA method at a concentration of 10 μM, and the effects of the derivatives on the host cell viability were evaluated at the same concentration. Fourteen compounds showed at least 80% inhibition, with only minor changes in host cell viability. Nine most potential compounds were evaluated using immunofluorescence microscopy on two different strains of C. pneumoniae CWL-029 and CV-6. The N-[3-(1H-benzimidazol-2-yl)phenyl]-3-methylbenzamide (42) had minimal inhibitory concentration (MIC) of 10 μM against CWL-029 and 6.3 μM against the clinical strain CV-6. This study shows the high antichlamydial potential of 2-arylbenzimidazoles, which also seem to have good characteristics for lead compounds.

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