- Palladium-Catalyzed meta-C-H Olefination of Arene-Tethered Diols Directed by Well-Designed Pyrimidine-Based Group
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The palladium-catalyzed meta-olefination of arene-tethered diols attached to a well-designed pyrimidine moiety is presented. Applications of the protocol are illustrated by the synthesis of various diol-based natural products, such as coumarins, phenylpropanoids, stilbenes, and chalcones. Advantages of this method are demonstrated through the easy removal of the template and a gram-scale olefination reaction. Finally, experimental verification, including 1H NMR, ESI-MS and IR, and DFT studies are undertaken to elucidate the mechanistic complexity.
- Fang, Siqiang,Wang, Xiaobing,Yin, Fucheng,Cai, Pei,Yang, Huali,Kong, Lingyi
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supporting information
(2019/03/19)
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- Palladium-Catalyzed Regioselective Allylation of Chloromethyl(hetero)arenes with Allyl Pinacolborate
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The palladium-catalyzed regioselective allylation reaction between chloromethyl(hetero)arenes and allyl pinacolborate is reported in this work. Chloromethylarenes smoothly reacted with allyl pinacolborate, producing para-allylated dearomatization products
- Zhang, Sheng,Ullah, Aziz,Yamamoto, Yoshinori,Bao, Ming
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supporting information
p. 2723 - 2728
(2017/08/23)
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- Palladium-Catalyzed sp2-sp3 Coupling of Chloromethylarenes with Allyltrimethoxysilane: Synthesis of Allyl Arenes
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Palladium-catalyzed remote sp2-sp3 coupling reaction of chloromethylarenes with allyltrimethoxysilane is described in this work. The allylation reaction regioselectively occurred on the para-positions of 1-(chloromethyl)naphthalenes
- Zhang, Sheng,Cai, Jinfang,Yamamoto, Yoshinori,Bao, Ming
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p. 5974 - 5980
(2017/06/07)
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