429682-68-8

Basic information

• Product Name: 4-BROMO-5-ACETAMIDOINDANONE
• Synonyms: 4-BROMO-5-ACETAMIDOINDANONE;N-(4-BroMo-1-oxo-2,3-dihydro-1H-inden-5-yl)acetaMide
• CAS NO: 429682-68-8
• Molecular Formula: C₁₁H₁₀BrNO₂
• Molecular Weight: 268.12
• Mol File: 429682-68-8.mol

Chemical Properties

• Boiling Point: 471.2°C at 760 mmHg
• Flash Point: 238.7°C
• Appearance: /
• Density: 1.631g/cm³
• Vapor Pressure: 4.77E-09mmHg at 25°C
• Refractive Index: 1.658
• PKA: 13.60±0.20(Predicted)
• CAS DataBase Reference: 4-BROMO-5-ACETAMIDOINDANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-5-ACETAMIDOINDANONE(429682-68-8)
• EPA Substance Registry System: 4-BROMO-5-ACETAMIDOINDANONE(429682-68-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 429682-68-8(Hazardous Substances Data)

Usage

Uses

Due to the limited information available on 4-Bromo-5-acetamidoindanone, its applications are not well-defined. However, based on its chemical structure and classification as a brominated ketone, potential uses in the following industries can be hypothesized:
Used in Pharmaceutical Industry:
4-Bromo-5-acetamidoindanone could be used as an intermediate compound in the synthesis of pharmaceutical drugs, given its unique molecular structure. Its potential reactivity and interaction with other molecules might be explored for the development of new drug candidates.
Used in Chemical Research:
In the field of chemical research, 4-Bromo-5-acetamidoindanone may serve as a subject for studying the properties and behavior of brominated ketones. This could contribute to a better understanding of the reactivity and potential applications of similar compounds.
Used in Material Science:
4-BROMO-5-ACETAMIDOINDANONE's unique structure and properties might make it a candidate for use in the development of new materials with specific characteristics, such as improved thermal stability or chemical resistance, in the material science industry.

InChI:InChI=1/C11H10BrNO2/c1-6(14)13-9-4-2-7-8(11(9)12)3-5-10(7)15/h2,4H,3,5H2,1H3,(H,13,14)

Upstream product

• 59856-06-3 5-acetamidoindane 
• 24425-40-9 indan-5-amine 
• 58161-35-6 5-acetamido-1-indanone 

Downstream Products

• 851107-75-0 N-(2-benzylidene-4-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide 
• 851107-76-1 N-(2-benzyl-4-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide 
• 909555-29-9 N-[2-(2-fluorobenzyl)-4-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl]acetamide 
• 909555-28-8 N-[2-(3-fluorobenzyl)-4-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl]acetamide 
• 851107-73-8 N-[2-(4-fluorobenzyl)-4-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl]acetamide 
• 851107-72-7 N-{2-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-4-methyl-1-oxo-indan-5-yl}-acetamide 
• 909555-31-3 7-amino-9a-benzyl-4,8-dimethyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one 
• 851107-80-7 9a-benzyl-6-bromo-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one 
• 851107-79-4 N-(9a-benzyl-4-bromo-8-methyl-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)acetamide 
• 851107-77-2 N-(9a-benzyl-8-methyl-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)acetamide 
• 909555-32-4 7-amino-9a-(3-fluorobenzyl)-4,8-dimethyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one 
• 851107-74-9 7-amino-9a-(4-fluorobenzyl)-4,8-dimethyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one 
• 909555-33-5 7-amino-9a-(2-fluorobenzyl)-4,8-dimethyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one 
• 851107-78-3 N-(9a-benzyl-4-bromo-8-methyl-3-oxo-2,3,9,9a-tetrahydro-1H-fluoren-7-yl)acetamide 

Relevant articles and documents

Synthesis of bromoaminoindane and bromoaminoindanone derivatives

The bromination reactions of 5-aminoindane, 5-acetamidoindane, and 5-acetamidoindan-1-one were investigated using NBS, molecular bromine and photobromination, and the optimum reaction conditions were presented. The reaction of 5-aminoindane with glacial acetic acid at reflux temperature resulted in the formation of 5-acetamidoindane in high yield. 5-Acetamidoindan-1-one was generated by the reaction of 5-acetamidoindane with CrO3 in acetic acid. Selective bromination at C-6 position of 5-acetamidoindane was achieved by treatment of title compound with bromine in acetic acid and thus afforded 5-acetamido-6-bromoindane. Further bromination reactions of bromoindanones were achieved in various reaction conditions.

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies

A strategy to obtain a fully orthogonal estrogen-receptor-based gene switch responsive to molecules with acceptable pharmacological properties is presented. From a series of tetrahydrofluorenones active on the wild-type estrogen receptor (ER) an inactive