- 3,5,7-TRISUBSTITUTED PYRAZOLO[1,5-a]PYRAMIDINES
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3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines are disclosed of the general formula wherein R1 is CF3 or C1-C9 alkyl; R2 is CF3 or C1-C9 alkyl; and R3 is halogen. Such compounds are useful as inhibitors of 3',5'-cyclic AMP phosphodiesterase enzyme
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- 3 Substituted 5,7 dimethylpyrazolo[1,5 α]pyrimidines, 3',5' cyclic AMP phosphodiesterase inhibitors. 1
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A series of 3 substituted 5,7 dimethylpyrazolo[1,5 α]pyrimidines were synthesized and evaluated for their ability to inhibit the enzyme 3',5' cyclic AMP phosphodiesterase that was isolated and purified from rabbit kidney, rabbit lung, and beef heart. The 3 bromo, 3 chloro, 3 iodo, and 3 acetyl derivatives were found to be more potent than theophylline in their ability to inhibit these 3',5' cAMP phosphodiesterases.
- Novinson,Hanson,Dimmitt,Simon,Robins,O'Brien
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p. 645 - 648
(2007/10/05)
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