- New synthesis of [1,3,4] thiadiazolo [2,3-c][1,2,4] triazinone; transfer of active electron by microwaves
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Reaction of various aromatic aldehydes with 4-amino-6-methyl-1,2,4-triazin-5-one supported on to montmorillonite-K10 in the presence of nitrobenzene under microwaves irradiation, afforded the corresponding [1,3,4] thiadiazole [2,3-c][1,2,4]-triazinones.
- Abdi Oskooie,Heravi,Khosrofar,Faridbod
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- Synthesis and biological studies of some new thiadiazolo [2,3-a] 1,2,4-triazin-5-ones
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Treatment of thiocarbohydrazide 2 with pyruvic acid 1 in ethanol affords 4-amino-3-mercapto-6-methyl-1,2,4-triazin-5(4H)-one 3. Cyclization of 3 with various aromatic acids in presence of phosphorus oxychloride yields 2-substituted -6-methyI-4H-1,3,4-thiadiazolo [2,3-c], 1,2,4-triazin-5-ones (4a-j). The structures of the newly synthesized compounds have been established by means of IR, Mass, 1H NMR spectral data. All the new compounds (4a-j) were evaluated for their antibacterial and antifungal activities.
- Revanasiddappa,Subrahmanyam,Satyanarayana
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experimental part
p. 291 - 292
(2011/12/05)
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