43039-98-1

Basic information

• Product Name: 2-PROPIONYLTHIAZOLE
• Synonyms: 1-(2-thiazolyl)-1-propanon;2-propionylthiazol;2-propionyl-thiazol;2-thiazolyl-1-propanone;Thiazole, 2-(1-oxopropyl);Thiazole, 2-propionyl-;ETHYL 2-THIAZOLYL KETONE;FEMA NUMBER 3611
• CAS NO: 43039-98-1
• Molecular Formula: C₆H₇NOS
• Molecular Weight: 141.19
• Product Categories: thiazole Flavor
• Mol File: 43039-98-1.mol

Chemical Properties

• Boiling Point: 110°C/5mm
• Flash Point: 110°C/5mm
• Appearance: /
• Density: 1.174
• Vapor Pressure: 0.0836mmHg at 25°C
• Refractive Index: 1.5350-1.5390
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.03±0.10(Predicted)
• Water Solubility: Not miscible or difficult to mix with water.
• CAS DataBase Reference: 2-PROPIONYLTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PROPIONYLTHIAZOLE(43039-98-1)
• EPA Substance Registry System: 2-PROPIONYLTHIAZOLE(43039-98-1)

Safety Data

• Hazard Codes: Xn
• Statements: 10-36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• RIDADR: 1993
• RTECS: XJ5123000
• HazardClass: IRRITANT
• Hazardous Substances Data: 43039-98-1(Hazardous Substances Data)

Usage

Occurrence

Reported found in lard.

Uses

Used as flavoring agent and fragrance chemical compounds.

InChI:InChI=1/C6H7NOS/c1-2-5(8)6-7-3-4-9-6/h3-4H,2H2,1H3

Upstream product

• 89464-29-9 2-(1-hydroxypropyl)thiazole 
• 3034-53-5 2-bromo-1,3-thiazole 
• 758-96-3 N,N-dimethyl-propanamide 
• 112969-95-6 1-(thiazol-2-yl)-prop-2-en-1-ol 

Downstream Products

• 134154-28-2 1-[4-(Naphthalen-2-ylmethoxy)-phenyl]-1-thiazol-2-yl-propan-1-ol 
• 134154-27-1 1-[2-(Naphthalen-2-ylmethoxy)-phenyl]-1-thiazol-2-yl-propan-1-ol 
• 134154-06-6 2-{1-Methoxy-1-[4-(naphthalen-2-ylmethoxy)-phenyl]-propyl}-thiazole 
• 134154-05-5 2-{1-Methoxy-1-[2-(naphthalen-2-ylmethoxy)-phenyl]-propyl}-thiazole 

Relevant articles and documents

Aerobic oxidation of secondary benzylic alcohols and direct oxidative amidation of aryl aldehydes promoted by sodium hydride

We reported herein new reactivities and possible mechanistic implications of a simplest oxidant (NaH/air) uncovered on a broad range of useful transformations, including aerobic alcohol oxidations, allylic alcohol isomerizations and oxidations, cyclopropyl alcohol fragmentations, and direct aryl aldehyde oxidative amidations. These readily implementable transition-metal-free processes feature exceptional material accessibility, operational simplicity, and environmental compatibility, and add new dimensions to its synthetic utilities that are fairly robust yet had not previously been fully realized and systematically explored.

(Methoxyalkyl)thiazoles: A new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity

(Methoxyalkyl)thiazoles are novel 5-lipoxygenase (5-LPO) inhibitors that are neither redox agents nor iron chelators. Consideration of a hypothetical model of the enzyme active site led to this series which is exemplified by 1-[3(naphth-2-ylmethoxy)phenyl]-1-(thiazol-2-yl)propyl methyl ether (2d, ICI211965). 2d inhibits cell-free guinea pig 5-LPO activity, LTC4 synthesis in plasma free mouse macrophages, and LTB4 synthesis in rat and human blood (IC50s 0.1 μM, 8nM, 0.5 μM, and 0.4 μM, respectively) but does not inhibit the synthesis of cyclooxygenase products at concentrations up to 50 μM in macrophages and 100 μM in blood. 2d is orally active in rat (ex vivo ED50 10 mg/kg in blood taken in 1h after dosing). SAR studies show that high in vitro potency requires methoxy, thiazolyl, and naphthyl groups and depends critically on the substitution pattern. (Methoxyalkyl)thiazoles are chiral. Resolution of 1-methoxy-6-(naphth-2-ylmethoxy)-1-(thiazol-2-yl)indan (2j, ICl216800) shows that (+)-2j is 50-150-fold more potent than (-)-2j in in vitro assays. Thus, (methoxyalkyl)thiazoles are a new series of orally active, selective 5-LPO inhibitors and represent the first class of inhibitors in which inhibition is mediated by specific, enantioselective interactions with the enzyme.