430457-82-2

Basic information

• Product Name: N-cyclopentyl-4-phenylbutanamide
• Synonyms: N-cyclopentyl-4-phenylbutanamide
• CAS NO: 430457-82-2
• Molecular Formula: C15H21NO
• Molecular Weight: 231.33
• Mol File: 430457-82-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-cyclopentyl-4-phenylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclopentyl-4-phenylbutanamide(430457-82-2)
• EPA Substance Registry System: N-cyclopentyl-4-phenylbutanamide(430457-82-2)

Safety Data

• Hazardous Substances Data: 430457-82-2(Hazardous Substances Data)

Upstream product

• 56229-85-7 N,N-diethyl-4-phenylbutanamide 
• 1003-03-8 Cyclopentamine 

Relevant articles and documents

Tungsten-Catalyzed Transamidation of Tertiary Alkyl Amides

Transamidation has recently emerged as a straightforward and convenient means to diversify amides. However, the kinetically and thermodynamically demanding transamidation of notoriously robust, fully alkyl-substituted tertiary amides still remains a longstanding challenge. Here, we describe a method for the activation of tertiary alkyl amides to streamline transamidation using simple tungsten(VI) chloride as a catalyst and chlorotrimethylsilane as an additive. The highly electrophilic and oxophilic tungsten catalyst enables the selective scission of a C-N bond of tertiary alkyl amides to effect transamidation of a myriad of structurally and electronically diverse tertiary alkyl amides and amines. Mechanistic study implies that the synergistic effect of the catalyst and the additive could pronouncedly induce the nucleophilic acyl substitution of tertiary alkyl amide with amine to realize transamidation.