- Asymmetric Pd-Catalyzed Alkene Carboamination Reactions for the Synthesis of 2-Aminoindane Derivatives
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A new type of Pd-catalyzed alkene carboamination reaction that provides direct access to enantioenriched 2-aminoindanes from 2-allylphenyltriflate derivatives and aliphatic amines is described. A catalyst generated in situ from Pd(OAc)2 and (S)-tert-butylPHOX provides the functionalized carbocycles in good yield with up to >99:1 er. The transformations occur via a key anti-aminopalladation that involves intermolecular attack of an amine nucleophile on an arylpalladium alkene complex.
- White, Derick R.,Hutt, Johnathon T.,Wolfe, John P.
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p. 11246 - 11249
(2015/09/21)
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- PYRIDOPYRIMIDINONE INHIBITORS OF KINASES
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The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
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Paragraph 0398
(2013/05/08)
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- PYRIDOPYRIMIDINONE INHIBITORS OF KINASES
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The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions cont
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Paragraph 0615
(2013/09/12)
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- 2 Aminoindans of pharmacological interest
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2 Aminoindans in which the amine moiety consists of various cyclic amine derivatives including morpholino, hexamethyleneimino (potential sympathomimetic agents), and 4 acyloxy 4 phenylpiperidino derivatives (potential analgetic agents) were prepared and t
- Solomons,Sam
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p. 1330 - 1333
(2007/10/05)
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