Copper catalyzed magnesium-Barbier reaction for γ-selective alkyl-allyl coupling
CuCN catalyzed alkyl-allyl coupling under magnesium-Barbier conditions occurs regioselectively and affords predominantly the γ-products in good to high yields. This one-pot CuCN catalyzed reaction utilising Mg, an alkyl halide and an allylic substrate in THF at room temperature provides an easy alternative to the classical CuCN catalyzed γ-allylation of alkyl Grignard reagents.
Erdik, Ender,Ko?o?lu, Melike
p. 4211 - 4214
(2008/02/08)
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