- Discovery of isoliquiritigenin analogues that reverse acute hepatitis by inhibiting macrophage polarization
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Screening a natural product library of 850 compounds yield isoliquiritigenin as an effective anti-inflammatory agent by inhibiting the production of pro-inflammatory NO induced by Pam3CSK4, while its activity accompanied by toxicity. Further studies obtained the optimized isoliquiritigenin derivative SMU-B14, which can inhibit Pam3CSK4 triggered toll-like receptor 2 (TLR2) signaling with low toxicity and high potency. Preliminary mechanism studies indicated that SMU-B14 worked through TLR2/MyD88, phosphorylation of IKKα/β, leading to the reduce degradation of NF-κB related IKBα and p65 complex, then inhibited the production of inflammatory cytokines, such as TNF-α, IL-6, IL-1β both in human and murine cell lines. Subsequent polarization experiments showed SMU-B14 significant reversed the polarization of M1 phenotype primary macrophage activated by Pam3CSK4 in vitro, and reduced the infiltration of neutrophil and polarization of M1-type macrophage, decreased serum alanine transaminase (ALT), as a result protected liver from being injured in vivo. In summary, we obtained an optimized lead compound SMU-B14 and found it functionally blocked TLR2/MyD88/NF-κB signaling pathway to down-regulate the production of inflammatory cytokines resulted significant liver protection property.
- Yang, Junjie,Hu, Fanjie,Guo, Chengjun,Liang, Yuqing,Song, Haiying,Cheng, Kui
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- Preparation and identification of aromatic copolyester containing chalcone groups
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In the present paper, many unsaturated polyesters has been synthesized using maleic anhydride, phthalic anhydride and succinic anhydride for esterification with new monomer [E)-1-(4-hydroxyphenyl)-3-(3-methoxy-4-hydroxyphenyl) prop-2-en- 1-one]. These pol
- Hassen, Huda Sabah,Khazaal, Majida Hameed,Majeed, Nadia Sadiq,Hassan, Ekhlas Sabah
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p. 4173 - 4181
(2021/07/31)
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- PYRIMIDINONE DERIVATIVES AND USES THEREOF TO NEUTRALIZE THE BIOLOGICAL ACTIVITY OF CHEMOKINES
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A subject of the present invention is a compound having the general formula (I) a pharmaceutically acceptable salt thereof or a tautomeric form thereof, wherein A, B3, B4, B5, Y, X, B1 and B2 are as defined in any one of claims 1 to 10. Another subject of the invention is the compound as defined above for use as a medicament, in particular for preventing and/or treating inflammation and inflammatory diseases, immune and auto-immune diseases, pain related diseases, genetic diseases and/or cancer.
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Page/Page column 27; 29; 30
(2018/02/28)
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- Design, Synthesis, and Docking Study of Pyrimidine–Triazine Hybrids for GABA Estimation in Animal Epilepsy Models
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A series of new pyrimidine–triazine hybrids (4a–t) was designed and synthesized, from which potent anticonvulsant agents were identified. Most of the compounds exhibited promising anticonvulsant activity against the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests, along with minimal motor impairment with higher safety compared to the standard drugs, phenytoin and carbamazepine. In the series, 5-(4-(4-fluorophenyl)-6-(4-hydroxyphenyl)-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl)-1,2-dihydro-1,2,4-triazin-3(6H)-one (4o) and 5-(6-(4-hydroxy-3-methoxyphenyl)-4-(4-hydroxyphenyl)-2-thioxo-5,6-dihydropyrimidin-1(2H)-yl)-1,2-dihydro-1,2,4-triazin-3(6H)-one (4s) emerged as most potent anticonvulsant agents with median doses of 22.54 and 29.40 mg/kg (MES ED50), 285.02 and 293.42 mg/kg (scPTZ ED50), and 389.11 and 412.16 mg/kg (TD50), respectively. Docking studies were also performed for all synthesized compounds to get insight into the binding pattern toward the GABAA receptor as a possible mechanism of their anticonvulsant action, and in silico ADME studies were carried out to predict the safety and stability of the molecules. The increased GABA level in the experimental animals in the neurochemical estimation assay confirmed their GABAergic modulating activity. The most potent compounds were also evaluated for their neurotoxic and hepatotoxic effects. Fortunately, they did not show any sign of neurotoxicity or hepatotoxicity, suggesting that they have a broad spectrum of anticonvulsant activity with a large safety margin. Together, this research suggested that 4o and 4s may serve as leads in the discovery and development of new anticonvulsant drugs.
- Sahu, Meeta,Siddiqui, Nadeem,Naim, Mohd. Javed,Alam, Ozair,Yar, Mohammad Shahar,Sharma, Vidushi,Wakode, Sharad
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- Facile Microwave-assisted Synthesis of 1,3,5-Trisubstituted Pyrazoline Derivatives Incorporating Sulfonyl Moiety
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We developed an environmentally benign, convenient microwave-assisted process for the construction of 1,3,5-trisubstitued pyrazolines (10a~10f, 11a~11f, 12a~12f, 13a~13f). Chalcones, as the key intermedi- ates, were obtained by the condensation of each of appropriately substituted aromatic aldehydes (1~4) with 4-substituted acetophenones (5a~5f) via a Claisen-Schmidt reaction under the action of microwave irradiation. Cyclization of the chalcones (6a~6f, 7a~7f, 8a~8f, 9a~9f) with p-toluene sulfonhydrazide af- forded 1,3,5-trisubstitued pyrazoline derivatives using microwave-assisted process in 25 min and 140 watt power in glycol. The structures of targeted compounds were established by IR, 1H NMR, MS and ele- mental analysis. The results indicate that microwave-assisted synthetic process presents advantages in terms of enhancement in rate, decrease in reaction time, clean reaction and convenient operation.
- Liu, Fei,Yang, Jin-Feng,Liu, Hong,Wei, Wen-Zhen,Ma, Yan-Mei
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p. 254 - 260
(2016/04/19)
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- Synthesis of 1,2,3-triazole tethered bifunctional hybrids by click chemistry and their cytotoxic studies
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In view of the drug resistance with most of the currently used anticancer drugs, molecular hybrids of pyrazolyl chalcones and p-nitro benzyl functionalities tethered by triazole ring have been synthesised and evaluated for cytotoxic studies against three human cancer cell lines (THP, COLO-205, A-549). The results of the preliminary investigation exhibited marked dependence of the cytotoxic activity on the electronic factors. Placement of naphthyl (JGPT-11) and trimethoxy phenyl ring (JGPT-6) as ring A proved to be extremely beneficial in enhancing the cytotoxic potential. Thus we herein report the synthesis and cytotoxic studies of a new class of molecular hybrids. Detailed investigation on the biological mechanistic insights of JGPT-11 and 6 is under progress.
- Singh, Jagjeet,Sharma, Sahil,Saxena,Nepali, Kunal,Bedi, Preet Mohinder Singh
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p. 3160 - 3169
(2013/07/11)
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- Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors
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In this study, twenty 3,5-diaryl-4,5-dihydro-1H-pyrazole derivatives with hydroxyl(s) (1a-1p, 2a-2d) were synthesized and their inhibitory activity on mushroom tyrosinase was examined. The results showed that among these compounds, 1-(5-(3,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl) ethanone 1d was found to be the most potent tyrosinase inhibitor with IC 50 value of 0.301 μM. Kinetic study revealed that these compounds were competitive inhibitors of tyrosinase and their structure-activity relationships were investigated in this article.
- Zhou, Zhixuan,Zhuo, Jiaru,Yan, Sujun,Ma, Lin
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p. 2156 - 2162
(2013/05/08)
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- Chalcones as novel non-peptidic μ-calpain inhibitors
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In order to extend the scaffold of non-peptidic calpain inhibitor, we have designed and synthesized 14 chalcone derivatives categorized into two groups based on their structures. Compounds 7 (IC50 = 16.67 ± 0.42 μM) and 8 (IC50 = 16.
- Lee, Eunyoung,Jang, Inhye,Shin, Min Jung,Cho, Hee-Ju,Kim, Jungsook,Eom, Ji-Eun,Kwon, Youngjoo,Na, Younghwa
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experimental part
p. 3459 - 3464
(2012/01/19)
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- Comparative study of conventional and microwave assisted synthesis of chalcones
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An efficient, facile and eco-friendly microwave assisted approach for the synthesis of substituted chalcones by condensation of substituted acetophenones with substituted benzaldehyds in presence of an inorganic base is desired over time consuming convent
- Sharma, Bhavana
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experimental part
p. 2468 - 2470
(2012/01/14)
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- Synthesis and evaluation of antiinflammatory activity of substituted chalcone derivatives
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In an effort to develop potent antiinflammatory agents, a series of substituted chalcone derivatives was synthesized and evaluated for antiinflammatory activity through monitoring of their ability to inhibit xylene-induced ear edema in mice. Some of the tested compounds exhibited significant activity, and compounds 3f [(E)-1-(2,4-dihydroxyphenyl)-3-(4- dimethylamino)phenyl)prop-2-en-1-one] and 3h [(E)-3-(4-chlorophenyl)-1-(2,4- dihydroxyphenyl)prop-2-en-1-one] showed the highest antiinflammatory activity (62 and 68% inhibition, respectively, 2 h before administration), comparable with or even slightly more potent than the reference drug ibuprofen (53%). Furthermore, the structure-activity relationship of these substituted chalcone derivatives was demonstrated.
- Zhang, Xue-Wu,Zhao, Dong-Hai,Quan, Ying-Chun,Sun, Liang-Peng,Yin, Xiu-Mei,Guan, Li-Ping
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experimental part
p. 403 - 412
(2011/02/27)
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- 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone and its use in cosmetic and pharmaceutical preparations
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The present invention concerns applications of the compound of formula 1 in cosmetic or pharmaceutical preparations.
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- 3-(4-HYDROXY-3-METHOXYPHENYL)-1-(4-HYDROXYPHENYL)-1-PROPANONE AND USE THEREOF AS AN ANTIMICROBIAL ACTIVE INGREDIENT
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Antimicrobially active 3-(4-hydroxy-3-methoxyphenyl)-1 -(4-hydroxyphenyl)-1 - propanone of the following formula 1 is described, as is a method for producing this compound and the use thereof as an antimicrobial active ingredient. Formula (I).
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Page/Page column 11
(2009/03/07)
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- 3-(4-HYDROXY-3-METHOXYPHENYL)-1-(4-HYDROXYPHENYL)-1-PROPANONE AND ITS USE AS ANTIOXIDANT
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The present invention relates to 3-(4-hydroxy-3-methoxyphenyl)-1 -(4- hydroxyphenyl)-1 -propanone of formula (I), a method for preparation of the compound of formula (I) and its use as an antioxidant in formulations and products.
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Page/Page column 6
(2009/03/07)
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- USE OF 3-(4-HYDROXY-3-METHOXYPHENYL)-1-(4-HYDROXYPHENYL) PROPANE-1-ONE FOR IMPROVED SKIN CONTOURING OR AGAINST CELLULITE
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A cosmetic or dermatological preparation which is suitable for application to skin and comprises 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-propane-1-one in a concentration which is effective for at least one of increasing skin moisture content, mo
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Page/Page column 3
(2009/09/05)
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- Microwave-Accelerated SPOT-synthesis on cellulose supports
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Equation presented. We demonstrate that microwave irradiation can dramatically accelerate reaction rates for spatially addressable library synthesis on planar membrane supports. The development of a robust support/linker system, microwave-assisted synthesis of small molecule test libraries, and methods for solid-phase scale-up on cellulose are described.
- Bowman, Matthew D.,Jeske, Ryan C.,Blackwell, Helen E.
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p. 2019 - 2022
(2007/10/03)
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- Synthesis of benzylideneacetophenones and their inhibition of lipid peroxidation
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A series of benzylideneacetophenone derivatives have been synthesized and found to show potent inhibition of the lipid peroxidation (LPO) in rat liver microsomes. All 19 compounds prepared in this series are LPO inhibitors. The highest activity was found
- Arty, Indyah S.,Timmerman, Henk,Samhoedi, Mochammed,Sastrohamidjojo,Sugiyanto,Van Der Goot, Henk
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p. 449 - 457
(2007/10/03)
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