437658-65-6

Basic information

• Product Name: 1H-Imidazole-2-methanol, 4,5-dichloro-
• Synonyms: 1H-Imidazole-2-methanol, 4,5-dichloro-
• CAS NO: 437658-65-6
• Molecular Formula: C4H4Cl2N2O
• Molecular Weight: 166.99
• Mol File: 437658-65-6.mol

Chemical Properties

• Boiling Point: 436.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.691±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.40±0.10(Predicted)
• CAS DataBase Reference: 1H-Imidazole-2-methanol, 4,5-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-2-methanol, 4,5-dichloro-(437658-65-6)
• EPA Substance Registry System: 1H-Imidazole-2-methanol, 4,5-dichloro-(437658-65-6)

Safety Data

• Hazardous Substances Data: 437658-65-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Imidazole-2-methanol, 4,5-dichlorois used as an active pharmaceutical ingredient for its antifungal and antimicrobial properties, contributing to the development of treatments for various infections caused by fungi and bacteria.
Used in Chemical Synthesis:
1H-Imidazole-2-methanol, 4,5-dichlorois used as a building block in the synthesis of other chemical compounds, leveraging its unique structure to create novel molecules with potential applications in various fields.
Used in Industrial Applications:
1H-Imidazole-2-methanol, 4,5-dichloro-'s specific properties may also find use in industrial processes, where its chemical reactivity and structural features could be harnessed for specific technical or manufacturing purposes, although the exact applications are still under investigation.

Upstream product

• 50-00-0 formaldehyd 
• 15965-30-7 4,5-dichloroimidazole 

Relevant articles and documents

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Synthesis and calcium channel antagonist activity of new 1,4-dihydropyridine derivatives containing dichloroimidazolyl substituents

A group of dialkyl, dicycloalkyl and diaryl ester analogues of nifedipine (CAS 21829-25-4), in which the ortho-nitrophenyl group at position 4 is replaced by a 4,5-dichloroimidazolyl substituent, were synthesized and evaluated as calcium channel antagonists using the high K+ contraction of guinea-pig ileal longitudinal smooth muscle. The results for the symmetrical esters in alkyl esters series showed that increasing the length of the methylene chain in C3 and C5 ester substituents (from n = 0 to n = 2) increased the activity. When increasing of the length was accompanied by increase of the hindrance, the activity decreased. In the unsymmetrical diester series, the results showed when R1 is a small substituent (R1 = Me), increasing of the lipophilic property in R2 substituent increases the activity if this high lipophilicity is not accompanied by steric hindrance. The results demonstrate that in the unsymmetrical series, several compounds (benzyl methyl, benzyl isopropyl and cyclohexyl ethyl) had activity similar to that of the reference drug nifedipine. In symmetrical diesters compounds, the most active compound was the diphenethyl ester derivative being more active than nifedipine. These structure-activity data indicate that the 4-(4,5-dichloroimidazolyl) moiety is the bioisoester of 3-nitrophenyl and 2,3-dichlorophenyl moieties.