437708-86-6Relevant articles and documents
Looking for new antileishmanial derivatives in 8-nitroquinolin-2(1H)-one series
Kieffer, Charline,Cohen, Anita,Verhaeghe, Pierre,Hutter, Sébastien,Castera-Ducros, Caroline,Laget, Michèle,Remusat, Vincent,M'Rabet, Manel Kraiem,Rault, Sylvain,Rathelot, Pascal,Azas, Nadine,Vanelle, Patrice
, p. 282 - 294 (2015)
From a recently identified antileishmanial pharmacophore, a structure-activity relationship study was conducted by introducing various aminated, phenoxy or thiophenoxy moieties at position 4 of the 8-nitroquinolin-2(1H)-one scaffold, using SNAr
The discovery of quinoline derivatives, as NF-κB inducing kinase (NIK) inhibitors with anti-inflammatory effects in vitro, low toxicities against T cell growth
Song, Jianing,Zhu, Yuqin,Zu, Weidong,Duan, Chunqi,Xu, Junyu,Jiang, Fei,Wang, Xinren,Li, Shuwen,Liu, Chenhe,Gao, Qianqian,Li, Hongmei,Zhang, Yanmin,Tang, Weifang,Lu, Tao,Chen, Yadong
, (2020/11/24)
NIK is a critical regulatory protein of the non-classical NF-kB pathway, and its dysregulated activation has been proved to be one of the pathogenic factors in a variety of autoimmune diseases and inflammatory diseases. Nevertheless, its corresponding dev
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 4: 3-Alkyl-4-halo-6-nitroquipazines
Byung, Seok Moon,Byoung, Se Lee,Dae, Yoon Chi
, p. 4952 - 4959 (2007/10/03)
On the basis of the structure-activity relationship (SAR) of 4-chloro-6-nitroquipazine (Ki = 0.03 nM) and 3-fluoropropyl-6- nitroquipazine (Ki = 0.32 nM), 3-alkyl-4-halo-6-nitroquipazines were synthesized and tested for their potenti
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-Substituted 6-nitroquipazines
Se Lee, Byoung,Chu, Soyoung,Lee, Bon-Su,Yoon Chi, Dae,Song, Yun Seon,Jin, Changbae
, p. 811 - 815 (2007/10/03)
Eleven 4-substituted derivatives of 6-nitroquipazine were synthesized and evaluated for their abilities to displace [3H]citalopram binding to the rat cortical synaptic membranes. Among them, 4-chloro-6-nitroquipazine was shown to possess the hi