New approaches to side-chain fluorinated bioimidazoles: 4-alkynylimidazoles as substrates for fluorination
4-Alkynylimidazoles have been prepared and their behavior as substrates for "FBr" addition (NBS+Et3N·3HF) have been studied. Facile Markownikov addition to ethylnylimidazole 2 gave fluorobromoolefin 9a, a potential synthon for the 2-imidazolyl-
Dolensky, Bohumil,Kirk, Kenneth L.
p. 105 - 110
(2007/10/03)
New building blocks for fluorinated bioimidazole derivatives II: Preparation of β-fluorourocanic acids
Replacement of vinyl hydrogen with fluorine is based on addition of an FBr equivalent to a double bond followed by HBr elimination. This sequence has been adapted to prepare 3-fluoro-3-imidazolylpropenoic acids (β-fluorourocanic acids), and the related fl
Dolensky, Bohumil,Kirk, Kenneth L.
p. 3468 - 3473
(2007/10/03)
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