439096-19-2

Basic information

• Product Name: 1-(2,6-DICHLOROBENZYL)TETRAHYDRO-4(1H)-PYRIDINONE
• Synonyms: 1-(2,6-DICHLOROBENZYL)TETRAHYDRO-4(1H)-PYRIDINONE;1-(2,6-dichloro-benzyl)-piperidin-4-one;1-[(2,6-dichlorophenyl)methyl]piperidin-4-one
• CAS NO: 439096-19-2
• Molecular Formula: C₁₂H₁₃Cl₂NO
• Molecular Weight: 258.14
• Mol File: 439096-19-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2,6-DICHLOROBENZYL)TETRAHYDRO-4(1H)-PYRIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-DICHLOROBENZYL)TETRAHYDRO-4(1H)-PYRIDINONE(439096-19-2)
• EPA Substance Registry System: 1-(2,6-DICHLOROBENZYL)TETRAHYDRO-4(1H)-PYRIDINONE(439096-19-2)

Safety Data

• Hazardous Substances Data: 439096-19-2(Hazardous Substances Data)

Upstream product

• 41979-39-9 4-piperidone hydrochloride 
• 20443-98-5 2,6-Dichlorobenzyl bromide 

Relevant articles and documents

Structure-Based Design and Synthesis of Piperidinol-Containing Molecules as New Mycobacterium abscessus Inhibitors

Non-tuberculous mycobacterium (NTM) infections, such as those caused by Mycobacterium abscessus, are increasing globally. Due to their intrinsic drug resistance, M. abscessus pulmonary infections are often difficult to cure using standard chemotherapy. We previously demonstrated that a piperidinol derivative, named PIPD1, is an efficient molecule both against M. abscessus and Mycobacterium tuberculosis, the agent of tuberculosis, by targeting the mycolic acid transporter MmpL3. These results prompted us to design and synthesize a series of piperidinol derivatives and to determine the biological activity against M. abscessus. Structure-activity relationship (SAR) studies pointed toward specific sites on the scaffold that can tolerate slight modifications. Overall, these results identified FMD-88 as a new promising active analogue against M. abscessus. Also, we determined the pharmacokinetics properties of PIPD1 and showed that intraperitoneal administration of this compound resulted in promising serum concentration and an elimination half-life of 3.2 hours.

PESTICIDAL SUBSTITUTED PIPERIDINES

The invention relates to the use of piperidine derivatives encompassed from the general formula (I) for the control of pests, including arthropods and helminths, and a method for the control of pests.