439117-40-5

Basic information

• Product Name: TERT-BUTYL [4-CHLORO-2-(HYDROXYMETHYL)BENZYL]CARBAMATE
• Synonyms: TERT-BUTYL [4-CHLORO-2-(HYDROXYMETHYL)BENZYL]CARBAMATE
• CAS NO: 439117-40-5
• Molecular Formula: C₁₃H₁₈ClNO₃
• Molecular Weight: 271.73992
• Mol File: 439117-40-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TERT-BUTYL [4-CHLORO-2-(HYDROXYMETHYL)BENZYL]CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL [4-CHLORO-2-(HYDROXYMETHYL)BENZYL]CARBAMATE(439117-40-5)
• EPA Substance Registry System: TERT-BUTYL [4-CHLORO-2-(HYDROXYMETHYL)BENZYL]CARBAMATE(439117-40-5)

Safety Data

• Hazardous Substances Data: 439117-40-5(Hazardous Substances Data)

Usage

Uses

Used in Agricultural Industry:
TERT-BUTYL [4-CHLORO-2-(HYDROXYMETHYL)BENZYL]CARBAMATE is used as an insecticide and acaricide for controlling a broad spectrum of pests such as ants, cockroaches, termites, and mites. It is applied to protect crops and maintain agricultural productivity by reducing damage caused by these pests.
Used in Non-Agricultural Settings:
In homes, gardens, and food storage facilities, TERT-BUTYL [4-CHLORO-2-(HYDROXYMETHYL)BENZYL]CARBAMATE is used as a pest control agent to manage and eliminate infestations of insects and mites. Its low toxicity to mammals and low environmental impact make it a suitable choice for these applications, ensuring the safety of humans and pets while effectively controlling pests.

Upstream product

• 21739-93-5 2-bromo-5-chlorobenzoic acid 
• 494210-98-9 methyl 5-chloro-2-[((trifluoromethyl)sulfonyl)oxy]benzoate 
• 439117-38-1 methyl 5-chloro-2-cyanobenzoate 
• 27007-53-0 methyl-2-bromo-5-chlorobenzoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 439117-39-2 [2-(aminomethyl)-5-chlorophenyl]methanol 

Downstream Products

• 439116-15-1 2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamine 
• 439118-00-0 (2-{[(azetidine-2-carbonyl)-amino]-methyl}-4-chloro-benzyl)-carbamic acid tert-butyl ester 
• 439117-44-9 (S)-tert-butyl 4-chloro-2-((pyrrolidine-2-carboxamido)methyl)benzylcarbamate 
• 486394-64-3 [4-Chloro-2-({[(S)-1-((R)-2-hydroxy-3,3-dimethyl-butyryl)-azetidine-2-carbonyl]-amino}-methyl)-benzyl]-carbamic acid tert-butyl ester 
• 439117-50-7 [4-Chloro-2-({[(S)-1-((R)-2-hydroxy-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-methyl)-benzyl]-carbamic acid tert-butyl ester 
• 439117-45-0 [4-Chloro-2-({[(S)-1-((R)-2-hydroxy-3,3-dimethyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-methyl)-benzyl]-carbamic acid tert-butyl ester 
• 439117-51-8 [4-Chloro-2-({[(S)-1-((R)-2-hydroxy-2-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-benzyl]-carbamic acid tert-butyl ester 
• 486394-58-5 [4-Chloro-2-({[(S)-1-((R)-3-cyclopropyl-2-hydroxy-3-methyl-butyryl)-azetidine-2-carbonyl]-amino}-methyl)-benzyl]-carbamic acid tert-butyl ester 
• 439117-46-1 [4-Chloro-2-({[(S)-1-((R)-2-cyclohexyl-2-hydroxy-acetyl)-pyrrolidine-2-carbonyl]-amino}-methyl)-benzyl]-carbamic acid tert-butyl ester 
• 439117-99-4 1-(N (fluorenylmethoxycarbonyl)-azetidin-2S-yl-carbonylaminomethyl)-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzene 
• 439117-43-8 N-fluorenylmethoxycarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide 

Relevant articles and documents

PYRROLIDINE THROMBIN INHIBITORS

Compounds of the invention, which may be useful in inhibiting thrombin and associated thrombotic occlusions, have the following structure: (I) or a pharmaceutically acceptable salt thereof, wherein R is a heterocycle or -(CR4R5)1-2NH2 , wherein R4 and R5,

Stereoselective synthesis of a potent thrombin inhibitor by a novel P2-P3 lactone ring opening

The concise synthesis of a potent thrombin inhibitor was accomplished by a mild lactone aminolysis between an orthogonally protected bis-benzylic amine and a diastereomerically pure lactone. The lactone was synthesized by the condensation of L-proline met

Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability

Modification of lead compound 1 by reducing lipophilicity in the P3 group produced a series of low molecular weight thrombin inhibitors with excellent potency in functional assays, metabolic stability, and oral bioavailability. These modifications led to

Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position

Thrombin inhibitors incorporating o-aminoalkylbenzylamides in the P1 position were designed, synthesized and found to have enhanced potency and selectivity in several different structural classes. X-ray crystallographic analysis of compound 24 bound in the α-thrombin-hirugen complex provides an explanation for these unanticipated results.

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: wherein R1 is, for example, hydrogen, Cl, or cyano, and R2 is, for example, hydrogen,

Thrombin inhibitors

Compounds of the invention are useful in inhibiting thrombin and treating blood coagulation and cardiovascular disorders and have the following structure: wherein R3 is hydrogen or halogen, and u is N or CH.