439579-12-1Relevant articles and documents
Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors
Lovering, Frank,Morgan, Paul,Allais, Christophe,Aulabaugh, Ann,Brodfuehrer, Joanne,Chang, Jeanne,Coe, Jotham,Ding, WeiDong,Dowty, Heather,Fleming, Margaret,Frisbie, Richard,Guzova, Julia,Hepworth, David,Jasti, Jayasankar,Kortum, Steve,Kurumbail, Ravi,Mohan, Shashi,Papaioannou, Nikolaos,Strohbach, Joseph W.,Vincent, Fabien,Lee, Katherine,Zapf, Christoph W.
, p. 606 - 621 (2018)
Many diseases are believed to be driven by pathological levels of reactive oxygen species (ROS) and oxidative stress has long been recognized as a driver for inflammatory disorders. Apoptosis signal-regulating kinase 1 (ASK1) has been reported to be activ