439587-17-4

Basic information

• Product Name: DL-4-Bromo-2-fluoropenylalanine
• Synonyms: DL-4-Bromo-2-fluoropenylalanine;4-BroMo-2-fluoro-DL-phenylalanine;4-Bromo-2-fluorophenyl-DL-alanine
• CAS NO: 439587-17-4
• Molecular Formula: C9H9BrFNO2
• Molecular Weight: 262.077
• Mol File: 439587-17-4.mol

Chemical Properties

• Boiling Point: 363.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.660±0.06 g/cm3(Predicted)
• PKA: 2.18±0.15(Predicted)
• CAS DataBase Reference: DL-4-Bromo-2-fluoropenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: DL-4-Bromo-2-fluoropenylalanine(439587-17-4)
• EPA Substance Registry System: DL-4-Bromo-2-fluoropenylalanine(439587-17-4)

Safety Data

• Hazardous Substances Data: 439587-17-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
DL-4-Bromo-2-fluoropenylalanine is used as a building block for the synthesis of various drug candidates and peptidomimetics, contributing to the development of new and more effective treatments.
Used in Enzyme and Receptor Inhibition:
DL-4-Bromo-2-fluoropenylalanine is used as an inhibitor of certain enzymes and receptors involved in various diseases, demonstrating its potential therapeutic properties.
Used in Understanding Molecular Interactions:
DL-4-Bromo-2-fluoropenylalanine is used as a valuable tool for understanding the interactions between small molecules and biological targets, aiding in the advancement of pharmaceutical research.

Upstream product

• 1213112-01-6 C₁₀H₁₁BrFNO₂ 
• 76283-09-5 4-bromo-2-fluorobenzyl bromide 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 

Relevant articles and documents

NOVEL SUBSTITUTED SPIROCYCLES

This invention relates to a compound of formula I wherein A and Cy have one of the meanings as indicated in the specification and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same and methods of using the same as agen

SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C

This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid(benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C

This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)- amides of formula (1) and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

SUBSTITUTED BICYCLIC 1-CARBOXYLIC-ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C

This invention relates to bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and their use in methods of treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C

This invention relates to 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

SUBSTITUTED 2-AZA-BICYCLO[2.2.2]OCTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C

This invention relates to 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. asthma and allergic diseases, gastrointestinal inflammatory diseases, eosinophilic diseases, chronic obstructive pulmonary disease, infection by pathogenic microbes, rheumatoid arthritis or atherosclerosis.

SUBSTITUTED BICYCLIC 1-CARBOXYLIC-ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C

This invention relates to bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

An improved "one-pot" procedure for synthesis of fluorinated DL-phenylalanines

DL-arylalanines were synthesized from corresponding aromatic aldehydes by an efficient "one-pot" procedure involving Erlenmeyer reaction and subsequent reduction of the resulting oxazolones (without prior isolation) using P/HI.