click synthesis of small-molecule inhibitors targeting caspases
A panel of 198 P4-diversified aldehyde (reversible) and vinyl sulfone (irreversible) inhibitors is successfully synthesized via an efficient click chemistry platform and directly screened against caspase-3 and -7 for inhibition. The Royal Society of Chemistry.
Ng, Su Ling,Yang, Peng-Yu,Chen, Kitty Y.-T.,Srinivasan, Rajavel,Yao, Shao Q.
supporting information; experimental part
p. 844 - 847
(2008/10/09)
Stereochemical control in the preparation of α-amino N-methylthiazolidine masked aldehydes used for peptide aldehydes synthesis
Chiral N-methyl thiazolidines masked α-amino aldehydes are used for solid phase peptide aldehyde elongation. Contrary to N-Boc-protected α-amino aldehydes, N-trityl protection secures the chiral integrity of the incoming aldehyde chiral C1′ carbon atom du
Gros, Christel,Boulègue, Cyril,Galeotti, Nathalie,Niel, Gilles,Jouin, Patrick
p. 2673 - 2680
(2007/10/03)
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