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441054-54-2

5-[4-(methylsulfonyl)phenyl]-2H-Tetrazole, also known as Temozolomide, is a cytotoxic and alkylating antineoplastic agent used in the treatment of various types of cancer, such as brain tumors and melanoma. It works by disrupting the growth and spread of cancer cells in the body. Temozolomide is a prodrug that is converted to the active metabolite, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC), which then alkylates DNA, leading to cell death.

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  • 441054-54-2 Structure

  • Basic information

    1. Product Name: 5-[4-(Methylsulfonyl)phenyl]-2H-tetrazole
    2. Synonyms: 5-[4-(Methylsulfonyl)phenyl]-2H-tetrazole
    3. CAS NO:441054-54-2
    4. Molecular Formula: C8H8N4O2S
    5. Molecular Weight: 224.23972
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 441054-54-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-[4-(Methylsulfonyl)phenyl]-2H-tetrazole(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-[4-(Methylsulfonyl)phenyl]-2H-tetrazole(441054-54-2)
    11. EPA Substance Registry System: 5-[4-(Methylsulfonyl)phenyl]-2H-tetrazole(441054-54-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 441054-54-2(Hazardous Substances Data)

441054-54-2 Usage

Uses

Used in Oncology:
5-[4-(methylsulfonyl)phenyl]-2H-Tetrazole is used as an antineoplastic agent for the treatment of various types of cancer, including brain tumors and melanoma. It is effective in disrupting the growth and spread of cancer cells, making it a valuable tool in oncology.
Used in Cancer Treatment:
5-[4-(methylsulfonyl)phenyl]-2H-Tetrazole is used as a cytotoxic and alkylating agent in the treatment of cancer. It is administered orally or intravenously, and its active metabolite, MTIC, alkylates DNA, leading to cell death and offering hope for patients with debilitating diseases.
Used in Drug Development:
5-[4-(methylsulfonyl)phenyl]-2H-Tetrazole serves as a prodrug in drug development, highlighting its potential for further research and development in the pharmaceutical industry. Its conversion to the active metabolite, MTIC, demonstrates its utility in the creation of new cancer treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 441054-54-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,1,0,5 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 441054-54:
(8*4)+(7*4)+(6*1)+(5*0)+(4*5)+(3*4)+(2*5)+(1*4)=112
112 % 10 = 2
So 441054-54-2 is a valid CAS Registry Number.

441054-54-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-[4-(Methylsulfonyl)phenyl]-2H-tetrazole

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:441054-54-2 SDS

441054-54-2Upstream product

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441054-54-2Relevant articles and documents

5-Aryltetrazoles from Direct C-H Arylation with Aryl Bromides

Zhang, Yuan,Lee, Jack Chang Hung,Reese, Matthew R.,Boscoe, Brian P.,Humphrey, John M.,Helal, Christopher J.

, p. 5718 - 5723 (2020/05/19)

A mild, direct C-H arylation of 1-substituted tetrazoles to 5-aryltetrazoles is developed using a Pd/Cu cocatalytic system with readily available aryl bromides. The methodology avoids late-stage usage of azides and tolerates a wide range of functionalities.

Excitatory amino acid receptor antagonists

-

, (2008/06/13)

The present invention provides compounds of Formula I or Formula II, or the pharmaceutically acceptable salts or prodrugs thereof, pharmaceutical compositions comprising compounds or Formula I or Formula II, and methods for treating neurological disorders and neurodegenerative diseases, particularly migraine.

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