444068-85-3

Basic information

• Product Name: N-(2-methoxyphenyl)-1-naphthamide
• Synonyms: N-(2-methoxyphenyl)-1-naphthamide
• CAS NO: 444068-85-3
• Molecular Formula: C₁₈H₁₅NO₂
• Molecular Weight: 277.3172
• Mol File: 444068-85-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-methoxyphenyl)-1-naphthamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methoxyphenyl)-1-naphthamide(444068-85-3)
• EPA Substance Registry System: N-(2-methoxyphenyl)-1-naphthamide(444068-85-3)

Safety Data

• Hazardous Substances Data: 444068-85-3(Hazardous Substances Data)

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 879-18-5 naphthalene-1-carbonic acid chloride 
• 86-55-5 1-naphthalenecarboxylic acid 

Relevant articles and documents

Palladium-Catalyzed Annulation of Arylbenzamides with Diaryliodonium Salts

By using diaryliodonium salts, a cylization has been accomplished in the synthesis of N-aryl phenanthridinone derivatives via a cascade of ortho-arylation and Csp2-N bond formation in the presence of palladium catalyst. The reaction exhibits a broad compatibility of readily available N-arylnaphthamides. (Figure presented.).

Preparation and biological properties of ring-substituted naphthalene-1-carboxanilides

In this study, a series of twenty- Two ring-substituted naphthalene-1- carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized carboxanilides was performed against Mycobacterium avium subsp. paratuberculosis. N-(2-Methoxyphenyl)naphthalene-1-carboxamide, N-(3-methoxyphenyl) naphthalene-1-carboxamide, N-(3-methylphenyl)naphthalene-1- carboxamide, N-(4-methylphenyl)naphthalene-1-carboxamide and N-(3-fluorophenyl)naphthalene-1- carboxamide showed against M. avium subsp. paratuberculosis two-fold higher activity than rifampicin and three-fold higher activity than ciprofloxacin. The most effective antimycobacterial compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. The testing of biological activity of the compounds was completed with the study of photosynthetic electron transport (PET) inhibition in isolated spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity expressed by IC50 value of the most active compound N-[4-(trifluoromethyl)phenyl]naphthalene-1- carboxamide was 59 μmol/L. The structure- Activity relationships are discussed.