444583-14-6

Basic information

• Product Name: Methyl 2-(isoindolin-1-yl)acetate
• Synonyms: Methyl 2-(isoindolin-1-yl)acetate
• CAS NO: 444583-14-6
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.22642
• Mol File: 444583-14-6.mol

Chemical Properties

• Boiling Point: 284.74°C at 760 mmHg
• Flash Point: 126.006°C
• Appearance: /
• Density: 1.111g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: Methyl 2-(isoindolin-1-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(isoindolin-1-yl)acetate(444583-14-6)
• EPA Substance Registry System: Methyl 2-(isoindolin-1-yl)acetate(444583-14-6)

Safety Data

• Hazardous Substances Data: 444583-14-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H13NO2/c1-14-11(13)6-10-9-5-3-2-4-8(9)7-12-10/h2-5,10,12H,6-7H2,1H3

Upstream product

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Relevant articles and documents

Simple Aza -conjugate addition methodology for the synthesis of isoindole nitrones and 3,4-dihydroisoquinoline nitrones

Aryl-aldehydes containing ortho-substituted α,β-unsaturated carboxylic acid derivatives react with hydroxylamine to afford reactive N-hydroxy-carbinolamine intermediates that undergo intramolecular aza-conjugate addition reactions to afford isoindole nitrones and 3,4-dihydroisoquinoline nitrones in good yield. Conditions have been developed to reduce these isoindole nitrones to their corresponding hydroxylamine, enamine, and amine derivatives. Isoindole nitrones react with dimethyl acetylenedicarboxylate (DMAD) via a [4 + 2]-cycloaddition/deamination pathway to afford substituted naphthalene derivatives, while 3,4-dihydroisoquinoline nitrones react with DMAD via a [1,3]-dipolar cycloaddition pathway to afford tricyclic heteroarenes.

Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor

A series of benzylic piperazines (e.g., 4 and 5) attached to an 'address element', the dipeptide H-d-Tic-d-p-Cl-Phe-OH, 3 has been identified as ligands for the melanocortin subtype-4 receptor (MC4R). We describe herein the structure-activity relationship (SAR) studies on the N-terminal residue of the 'address element'. Several novel dipeptides and reduced dipeptides with high MC4R binding affinities and selectivity emerged from this SAR study.

Piperazine- and piperidine-derivatives as melanocortin receptor agonists

The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.