444608-38-2

Basic information

• Product Name: Thiophene-3-ol, 4-aminotetrahydro-, 1,1-dioxide, (3S,4S)- (9CI)
• Synonyms: Thiophene-3-ol, 4-aminotetrahydro-, 1,1-dioxide, (3S,4S)- (9CI);(3S,4S)-3-amino-4-hydroxytetrahydrothiophene 1,1-dioxide
• CAS NO: 444608-38-2
• Molecular Formula: C4H9NO3S
• Molecular Weight: 151.18416
• Product Categories: ALCOHOL
• Mol File: 444608-38-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thiophene-3-ol, 4-aminotetrahydro-, 1,1-dioxide, (3S,4S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene-3-ol, 4-aminotetrahydro-, 1,1-dioxide, (3S,4S)- (9CI)(444608-38-2)
• EPA Substance Registry System: Thiophene-3-ol, 4-aminotetrahydro-, 1,1-dioxide, (3S,4S)- (9CI)(444608-38-2)

Safety Data

• Hazardous Substances Data: 444608-38-2(Hazardous Substances Data)

Upstream product

• 4509-11-9 3,4-epoxy-tetrahydro-thiophene-1,1-dioxide 
• 20688-38-4 rac-3-hydroxy-4-chlorotetrahydrothiophene-1,1-dioxide 

Downstream Products

• 98426-91-6 Acetic acid 4-acetylamino-1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl ester 
• 118787-55-6 1-Benzyl-3-((3R,4R)-4-hydroxy-1,1-dioxo-tetrahydro-1λ⁶-thiophen-3-yl)-thiourea 
• 86043-47-2 N-phenyl-N'-(4-hydroxy-1,1-dioxothiolan-3-yl)thiourea 
• 118787-58-9 N-benzoyl-N'-(1,1-dioxo-3-hydroxythiolan-4-yl)thiourea 

Relevant articles and documents

Kinase inhibitor compounds

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.

KINASE INHIBITOR COMPOUNDS

The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.

Structure-activity studies of cyclic ketone inhibitors of the serine protease plasmin: Design, synthesis, and biological activity

Three series of cyclic ketone inhibitors were synthesized and evaluated against the serine protease plasmin. Peptide inhibitors that incorporated 3-oxotetrahydrofuran and 3-oxotetrahydrothiophene 1,1-dioxide groups had the highest activities. Alkylamino substituents, which were designed to bind in the S1 subsite of plasmin, were attached to the inhibitors. Compounds 5c and 5g, which incorporated 6-aminohexyl substituents, were found to be optimal and demonstrated IC50 values in the low micromolar range. Incorporating conformationally constrained peptide segments into the inhibitors did not improve their activities.

Synthesis of novel, optically active, heterocyclic amino alcohols through desymmetrization of a C2-symmetric cyclic sulfate

A general and efficient method for the synthesis of optically active cis-4-amino-3-hydroxy-substituted heterocycles (1-4) has been developed through desymmetrization of a C2-symmetric cyclic sulfate chiron prepared from catalytic asymmetric dihydroxylation of 1,4-dichloro-trans-2-butene.