445430-61-5

Basic information

• Product Name: 1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one
• Synonyms: 1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one;4,5-dihydro-1,8-diMethyliMidazo(1,2-a)quinoxalin-4-one;IMidazo[1,2-a]quinoxalin-4(5H)-one, 1,8-diMethyl-
• CAS NO: 445430-61-5
• Molecular Formula: C12H11N3O
• Molecular Weight: 213.239
• Mol File: 445430-61-5.mol

Chemical Properties

• Appearance: /
• Density: 1.367g/cm³
• Refractive Index: 1.707
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one(445430-61-5)
• EPA Substance Registry System: 1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one(445430-61-5)

Safety Data

• Hazardous Substances Data: 445430-61-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one is utilized as a precursor in the synthesis of various pharmaceuticals due to its distinctive structure and biological properties. Its potential applications include the development of new drugs targeting a range of health conditions.
Used in Agrochemical Research:
In the agrochemical industry, 1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one serves as a starting material for the creation of novel agrochemicals, potentially leading to more effective and safer products for agricultural use.
Used in Antimicrobial Applications:
1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one is employed as an antimicrobial agent, leveraging its ability to combat various types of microorganisms, which can be instrumental in the development of new antibiotics and antifungal agents.
Used in Antitumor Applications:
1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one is also used as an antitumor agent, showing promise in the fight against cancer due to its potential to inhibit tumor growth and proliferation, offering a new avenue for cancer treatment.
Used in Antiviral Applications:
1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one is applied as an antiviral agent, indicating its potential to inhibit viral replication and activity, which could be crucial in developing treatments for viral infections.
Used in Organic Synthesis:
Furthermore, 1,8-dimethylimidazo[1,2-a]quinoxalin-4(5H)-one may be used as a building block in organic synthesis for the production of other significant chemical compounds, expanding its utility across various chemical and industrial applications.

InChI:InChI=1/C12H11N3O/c1-7-3-4-9-10(5-7)15-8(2)6-13-11(15)12(16)14-9/h3-6H,1-2H3,(H,14,16)

Upstream product

• 164329-73-1 4,5-dihydro-1,8-dimethylimidazo(1,2-a)quinoxalin-4-one-2-carboxylic acid 

Downstream Products

• 445430-62-6 4-chloro-1,8-dimethylimidazo(1,2-a) quinoxaline 

Relevant articles and documents

Imidazoquinoxaline compound for the treatment of melanoma

The present invention concerns a (4(2′-aminoethyl)amino-1,8-dimethylimididazo(1,2-a)quinoxaline)-4,5-dihydro-1,8-dimethylimidazo(1,2-a)quinoxalin-4-one-2-carboxylic acid (BMS-345541) or an analog thereof for the treatment of melanoma cancer. This compound inhibits NFκB activity and expression, and induces apoptosis in melanoma cancer cells. The present invention also provides a method for assaying for the inhibition of melanoma cancer cell growth.

Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK)

The present invention describes methods of preventing and treating inflammatory and immune-related diseases or disorders using inhibitors of IκB kinase (IKK). Also described are IKK inhibitors effective for the prevention and treatment of inflammatory and