446854-88-2Relevant articles and documents
Green and selective synthesis of N-substituted amides using water soluble porphyrazinato copper(II) catalyst
Ghodsinia, Sara S. E.,Akhlaghinia, Batool,Safaei, Elham,Eshghi, Hossein
, p. 895 - 903 (2013/08/23)
N,N',N",N"'-Tetramethyl tetra-2,3-pyridinoporphyrazinato copper(II) methyl sulfate ([Cu(2,3-tmtppa)](MeSO4)4) efficiently catalyzed the direct conversion of nitriles to N-substituted amides. The one pot selective synthesis of the N-substituted amides from nitriles and primary amines was performed in refluxing H2O. The catalyst was recovered and reused at least four times,maintaining its efficiency.