448196-03-0Relevant articles and documents
Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation
Natarajan, Amarnath,Guo, Yuhong,Harbinski, Frederick,Fan, Yun-Hua,Chen, Han,Luus, Lia,Diercks, Jana,Aktas, Huseyin,Chorev, Michael,Halperin, Jose A.
, p. 4979 - 4982 (2007/10/03)
Structure-activity relationship studies of substituted arylsulfoanilides as antiproliferatives, which are mediated by the partial depletion of intracellular Ca2+ stores, resulted in the identification of compounds with micromolar activity against lung cancer cells in a growth inhibition assay. Incorporating the substitution pattern of the best arylsulfoanilides onto the 3-phenyloxindole scaffold resulted in a potent arylsulfoanilide-oxindole hybrid, 27. Compound 27 inhibits cancer cell growth by partial depletion of intracellular Ca2+ stores and phosphorylation of eIF2α.