cas 4513-73-9, 4-METHOXY-3-METHYLPHENYLACETIC ACID | Articles data ｜lookchem

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4513-73-9

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Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents
A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.
Young, Jonathan R.,Huang, Song X.,Chen, Irene,Walsh, Thomas F.,DeVita, Robert J.,Wyvratt Jr., Matthew J.,Goulet, Mark T.,Ren, Ning,Lo, Jane,Yang, Yi Tien,Yudkovitz, Joel B.,Cheng, Kang,Smith, Roy G.
p. 1723 - 1727
(2007/10/03)

Studies on ketene and its derivatives. CIX. Synthesis of naturally occurring anthracene-9,10-diones
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Katagiri,Kato,Nakano
p. 2440 - 2446
(2007/10/02)

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Chemical Properties

Melting Point: 93 °C
Boiling Point: 313.4 °C at 760 mmHg
Flash Point:123.4 °C
Density: 1.146 g/cm³
Vapor Pressure: 0.000212mmHg at 25°C
Refractive Index: 1.534
PKA: 4.45±0.10(Predicted)
PSA: 46.53000
LogP: 1.63070

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