- SYNTHESIS
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The present invention relates to an improved process for the production of [(±)-endo]-4-amino-5-chloro-2-methoxy-N-(I-azabicyclo[3.3. 1]non-4-yl)benzamide hydrochloride, and intermediates thereof.
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Page/Page column 39
(2010/02/11)
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- SYNTHESIS
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The present invention provides processes for preparing Form II renzapride hydrochloride hydrate, crystalline Form II renzapride hydrochloride hydrate at a level of 75% of above and uses thereof.
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Page/Page column 4
(2008/06/13)
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- Synthesis
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The present invention provides an improved process for the production of [(±)-endo]-4-amino-5-chloro-2-methoxy-N-(1-azabicyclo[3.3.1]non-4-yl)benzamide hydrochloride, compositions thereof, and intermediates thereto.
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Page/Page column 11
(2010/02/11)
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- Pharmaceutically active tropanes
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A compound of the formula (I), and pharmaceutically acceptable salts thereof: STR1 wherein: R1 is a C1-6 alkoxy group; R2 and R3 are the same or different and are hydrogen, halogen, CF3, C2-7 acyl, C2-7 acylamino, or amino, aminocarbonyl or aminosulphone optionally substituted by one or two C1-6 alkyl groups, C1-6 alkylsulphone or nitro; R5 is hyrogen or C1-6 alkyl; R6 is C1-7 alkyl or a group --(CH2)s R7 where s is 0 to 2 and R7 is a C3-8 cycloalkyl group, or a group --(CH2)t R8 where t is 1 or 2 and R8 is C2-5 alkenyl or a phenyl group optionally substituted by one or two substituents selected from C1-6 alkyl, C1-4 alkoxy, trifluoromethyl and halogen; and n, p and q are independently 0 to 2; have useful pharmacological activity.
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- Pharmaceutically active aza-bicyclo-benzamide derivatives
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This invention relates to novel substituted benzamides having useful pharmacological properties, to pharmaceutical compositions containing them, and to a process for their preparation. N-(2-Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide, 1-ethyl-2(2-methoxy-5-sulphamoylbenzamidomethyl)pyrrolidine and N-[4'-(1 -benzyl)-piperidyl]-2-methoxy-4-amino-5-chlorobenzamide are well known compounds having useful pharmacological activity such as the ability to regulate the gastro-intestinal function anti-emetic activity and CNS activity. It has now been found that a certain structurally distinct class of substituted benzamides also has useful pharmacological activity, in particular dopamine antagonist activity.
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