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453565-47-4

N-Hydroxy-5-methyl-pyridine-2-carboxamidine is a pyridine derivative with the molecular formula C8H9N3O. It features a hydroxyl group and a carboxamidine group, and is utilized in organic synthesis for the preparation of drugs and pharmaceuticals. N-Hydroxy-5-methyl-pyridine-2-carboxamidine also serves as a catalyst in chemical reactions such as alcohol oxidation and heterocyclic compound synthesis. Its potential biological activities include antifungal and antibacterial properties, making it a versatile compound in both organic and medicinal chemistry.

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  • 453565-47-4 Structure

  • Basic information

    1. Product Name: N-Hydroxy-5-methyl-pyridine-2-carboxamidine
    2. Synonyms: N-Hydroxy-5-methyl-pyridine-2-carboxamidine
    3. CAS NO:453565-47-4
    4. Molecular Formula: C7H9N3O
    5. Molecular Weight: 151.17
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 453565-47-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 290.5±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.26±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 13.99±0.50(Predicted)
    10. CAS DataBase Reference: N-Hydroxy-5-methyl-pyridine-2-carboxamidine(CAS DataBase Reference)
    11. NIST Chemistry Reference: N-Hydroxy-5-methyl-pyridine-2-carboxamidine(453565-47-4)
    12. EPA Substance Registry System: N-Hydroxy-5-methyl-pyridine-2-carboxamidine(453565-47-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 453565-47-4(Hazardous Substances Data)

453565-47-4 Usage

Uses

Used in Organic Synthesis:
N-Hydroxy-5-methyl-pyridine-2-carboxamidine is used as a reagent in organic synthesis for the preparation of various drugs and pharmaceuticals. Its unique structure allows it to participate in a range of chemical reactions, contributing to the development of new medicinal compounds.
Used as a Catalyst:
In the chemical industry, N-Hydroxy-5-methyl-pyridine-2-carboxamidine is used as a catalyst to facilitate reactions such as the oxidation of alcohols and the synthesis of heterocyclic compounds. Its catalytic properties help to improve the efficiency and selectivity of these processes.
Used in Pharmaceutical Development:
Due to its potential biological activities, N-Hydroxy-5-methyl-pyridine-2-carboxamidine is studied for its applications in pharmaceutical development. Its antifungal and antibacterial properties are of particular interest, as they may lead to the creation of new treatments for infectious diseases.
Used in Research:
In academic and research settings, N-Hydroxy-5-methyl-pyridine-2-carboxamidine is utilized to explore its chemical properties and potential applications. Researchers investigate its reactivity, catalytic capabilities, and biological activities to expand the understanding of its role in chemistry and medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 453565-47-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,3,5,6 and 5 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 453565-47:
(8*4)+(7*5)+(6*3)+(5*5)+(4*6)+(3*5)+(2*4)+(1*7)=164
164 % 10 = 4
So 453565-47-4 is a valid CAS Registry Number.

453565-47-4Downstream Products

453565-47-4Relevant articles and documents

5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein

Malancona, Savina,Mori, Mattia,Fezzardi, Paola,Santoriello, Marisabella,Basta, Andreina,Nibbio, Martina,Kovalenko, Lesia,Speziale, Roberto,Battista, Maria Rosaria,Cellucci, Antonella,Gennari, Nadia,Monteagudo, Edith,Di Marco, Annalise,Giannini, Alessia,Sharma, Rajhans,Pires, Manuel,Real, Eleonore,Zazzi, Maurizio,Dasso Lang, Maria Chiara,De Forni, Davide,Saladini, Francesco,Mely, Yves,Summa, Vincenzo,Harper, Steven,Botta, Maurizio

supporting information, p. 766 - 772 (2020/07/14)

The HIV-1 nucleocapsid (NC) protein is a small basic DNA and RNA binding protein that is absolutely necessary for viral replication and thus represents a target of great interest to develop new anti-HIV agents. Moreover, the highly conserved sequence offers the opportunity to escape the drug resistance (DR) that emerged following the highly active antiretroviral therapy (HAART) treatment. On the basis of our previous research, nordihydroguaiaretic acid 1 acts as a NC inhibitor showing moderate antiviral activity and suboptimal drug-like properties due to the presence of the catechol moieties. A bioisosteric catechol replacement approach led us to identify the 5-dihydroxypyrimidine-6-carboxamide substructure as a privileged scaffold of a new class of HIV-1 NC inhibitors. Hit validation efforts led to the identification of optimized analogs, as represented by compound 28, showing improved NC inhibition and antiviral activity as well as good ADME and PK properties.

Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof

-

, (2008/06/13)

The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists

-

, (2008/06/13)

The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

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