453590-24-4

Basic information

• Product Name: 6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
• Synonyms: 6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE
• CAS NO: 453590-24-4
• Molecular Formula: C₁₃H₁₁N₃O₂
• Molecular Weight: 241.25
• Mol File: 453590-24-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE(453590-24-4)
• EPA Substance Registry System: 6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-4-AMINE(453590-24-4)

Safety Data

• Hazardous Substances Data: 453590-24-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-(4-Methoxyphenyl)furo[2,3-d]pyrimidin-4-amine is used as a potential active pharmaceutical ingredient for the development of new drugs. Its unique molecular structure may offer novel therapeutic properties, which could be harnessed to address various medical conditions.
Used in Agricultural Industry:
In agriculture, 6-(4-Methoxyphenyl)furo[2,3-d]pyrimidin-4-amine may be utilized as a component in the development of new pesticides or herbicides. Its specific chemical properties could provide innovative solutions for crop protection and management.
Used in Material Science:
6-(4-Methoxyphenyl)furo[2,3-d]pyrimidin-4-amine has potential applications in material science, where it could be employed in the synthesis of new materials with unique properties. These materials could have uses in various industries, such as electronics, textiles, or coatings, depending on the specific characteristics they exhibit.

Upstream product

• 26454-79-5 2-(2-(4-methoxyphenyl)-2-oxoethyl)malononitrile 
• 77287-34-4 formamide 
• 26454-83-1 2-amino-5-(4-methoxyphenyl)-furan-3-carbonitrile 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 501693-22-7 5-bromo-6-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-ylamine 

Relevant articles and documents

COMPOUND FOR INHIBITING TYROSINE KINASE ACTIVITY OF DDR2 PROTEIN

A new furopyrimidine compound, their pharmaceutically acceptable salt, and a tyrosine kinase activity inhibitor. The furopyrimidine compound is a compound defined by chemical formula 1, 2, 3 or 4, on their precursor, and can exist as a form of free base or in an acid-addition salt. Since the furopyrimidine compound has an effect of inhibiting activity of DDR2 tyrosine kinase, it can be used in treating illnesses caused by the DDR2 tyrosine kinase activity such as hepatocirrhosis, rheumatoid arthritis or cancer.

Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors

A novel class of furo[2,3-d]pyrimidines has been discovered as potent dual inhibitors of Tie-2 and VEGFR2 receptor tyrosine kinases (TK) and a diarylurea moiety at 5-position shows remarkably enhanced activity against both enzymes. One of the most active compounds, 4-amino-3-(4-((2-fluoro-5-(trifluoromethyl) phenyl)amino-carbonylamino)phenyl)-2-(4-methoxyphenyl)furo[2,3-d]pyrimidine (7k) is 3 nM on both TK receptors and the activity is rationalized based on the X-ray crystal structure.

NOVEL CHEMICAL COMPOUNDS

The present invention relates generally to inhibitors of the kinases, such as GSK-3, and more particularly to fused pyrimidine compounds.

4-Acylamino-6-arylfuro[2,3-d]pyrimidines: Potent and selective glycogen synthase kinase-3 inhibitors

Modeling studies of a furo[2,3-d]pyrimidine GSK-3 hit compound 1 superimposed onto the X-ray crystal structure of a legacy pyrazolo[3,4-c] pyridazine GSK-3 inhibitor 2 led to the identification of 4-acylamino-6- arylfuro[2,3-d]pyrimidine template 3. Synth