- METHOD FOR PRODUCING RECOMBINANT PEPTIDE AND RESULTANT PEPTIDE
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PROBLEM TO BE SOLVED: To provide peptides with reproductive- and sexual-function stimulating activity. SOLUTION: The peptides are represented by general formula: A-Thr-Lys-Pro-B-C-D-X (where A is 0, Met, Met(O), Thr, Ala, His, Phe, Lys, or Gly; B is 0, Gly, Asp, Trp, Gln, Asn, Tyr, Pro, or Arg; C is 0, Arg, Phe, Tyr, Gly, His, Pro, or Lys; D is 0, Val, Gly, Tyr, Trp, Phe, or His; and X is OH, OCH3, or NH2; where 0 represents absence of the amino acid residue; provided that if A≠0 then B ≠0 and/or C≠0 and/or D≠0, if B≠0 then C≠0 and/or D≠0, and peptides Phe-Thr-Lys-Pro-Gly, Thr-Lys-Pro-Pro-Arg and Thr-Lys-Pro-Arg-Gly are excluded). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPO&INPIT
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Paragraph 0063; 0067
(2020/01/07)
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- SYNTHESIS AND PROPERTIES OF PEPTIDE FRAGMENTS OF THE S-REGION OF THE SURFACE PROTEIN OF THE HEPTATITIS B VIRUS
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A peptide fragment with the 140-146 sequence of the main component of the surface protein of the hepatitis B virus (HBsAG) and a number of its structural analogues have been synthesized by the classical method in solution.Conjugates of the peptides synthesized with bovine serum albumin and with a synthetic polypeptide analogue of polytuftsin have been obtained.The ability of the preparations to bind antibodies from the blood sera of hepatitis B patients has been studied.The possibility has been shown of their use for revealing antibodies to the heptatitis B virus in solid-phase enzyme-mediated immunoassay.
- Kuranova, I. L.,Churkina, S. I.,Os'mak, A. V.,Filonova, E. B.,Lyudmirova, V. L.,Noskova, O. V.
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p. 355 - 361
(2007/10/02)
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- AMINO THIOL DIPEPTIDES
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Amino thiol substituted dipeptides of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
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- SYNTHESIS OF FRAGMENT 8-12 OF THE NATURAL SEQUENCE OF ACTH
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Two new variants of the synthesis of the pentapeptide 8-12 of the natural sequence of ACTH are presented.In some stages, the trimethylsilyl group was used as temporary protection of the carboxy group of the amino component.The final and intermediate compo
- Rabinovich, A. K.,Krysin, E. P.,Karel'skii, V. N.,Titova, E. V.
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