Synthesis and antiangiogenic activity of thioacetal artemisinin derivatives
Various thioacetal artemisinin derivatives can inhibit the angiogenesis and might be angiogenesis inhibitors. In particular, 10α- phenylthiodihydroartemisinins (5), 10β-benzenesulfonyl-9-epi- dihydroartemisinin (11) and 10α-mercaptodihydroartemisinin (13)
Oh, Sangtae,Jeong, In Howa,Ahn, Chan Mug,Shin, Woon-Seob,Lee, Seokjoon
Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells
A series of artemisinin dimers incorporating a metabolically stable C-10 carba-linkage have been prepared, several of which show remarkable in vitro antimalarial activity (as low as 30 pM) versus Plasmodium falciparum and in vitro anticancer activity in t
Chadwick, James,Mercer, Amy E.,Park, B. Kevin,Cosstick, Richard,O'Neill, Paul M.
experimental part
p. 1325 - 1338
(2009/08/15)
Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells
Thioacetal artemisinin derivatives, in particular, 10α -phenylthiodihydroartemisinins (5), 10β -benzenesulfonyl-9-epi-dihydroartemisinin (9) and 10α -mercaptodihydroartemisinin (11), exhibit good growth inhibition activity against HUVEC proliferation at t
Oh, Sangtae,Jeong, In Howa,Shin, Woon-Seob,Lee, Seokjoon
p. 3665 - 3668
(2007/10/03)
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