- Synthesis of polybenzoquinazolines via an intramolecular dehydration of photocyclization
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Benzo[h]-naphth[1,2-f]quinazolines and benzo[h]-phenanthren[9,10-f]quinazoines were synthesized from intermediates 4-(2-hydroxyphenyl)-5-(naphthalen-1-yl)pyrimidines and 4-(2-hydroxyphenyl)-5-(phenanthren-1-yl) pyrimidines by the intramolecular dehydration of photocyclization. The intermediates were obtained by the condensation of 3-arylchromone with formamidine, acetamidine or guanidine refluxing in ethanol, respectively. Irradiation of the corresponding intermediates by a high-pressure mercury lamp in 19:1 (v/v) [Formula presented]2O or 18:1:1 (v/v) [Formula presented]2O-Dioxane lead to target products. This photocyclization showed advantages including catalyst-free and mild reaction condition. Moreover, water was the only by-product of this reaction. The crystal structure of 2-amino-12-methoxy-benzo[h]-naphth[1,2-f]quinazoline was determined and the fluorescence properties of these polybenzoquinazolines were also investigated.
- Wei, Wei,Li, Chenchen,Wang, Tao,Liu, Dian,Zhang, Zunting
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p. 5037 - 5046
(2016/07/25)
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- Negishi coupling reactions as a valuable tool for [11C]methyl- arene formation; First proof of principle
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The Negishi coupling reaction between arylzinc halide reagents and 11CH3I has been used to synthesise 11C- methylated arene species via a palladium-mediated process. The metabotropic glutamate receptor subtype-5 radiotracer [11C]MPEP has been radiolabelled using this technique.
- Kealey,Passchier,Huiban
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supporting information
p. 11326 - 11328
(2013/12/04)
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