- Facile synthesis of 3-methoxycarbonyl-2,2,5,5-tetra-methylpyrrolidine-1-oxyl and derivatives
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We have achieved an efficient alternative synthesis of blood-brain-barrier permeable nitroxyl radicals 3-methoxycarbonyl-2,2,5,5-tetra-methylpyrrolidine-1-oxyl (1a) and 3-ethoxycarbonyl-2,2,5,5-tetramethylpyrroli-dine-1-oxyl (1b), which affords 1a and 1b in 65% isolated yields by four steps from 2,2,6.6-tetramethyl-4-piperidone (2), respectively. This protocol is applicable to the synthesis of 3-isopropoxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl (1c) and 3-carbonyl-2,2,5,5-tetramethylpyrro-lidine-1-oxyl (6).
- Hatano, Bunpei,Araya, Hiroki,Yoshimura, Yutaka,Sato, Haruna,Ito, Tomohiro,Ogata, Tateaki,Kijima, Tatsuro
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- A cyanine dye based supramolecular photosensitizer enabling visible-light-driven organic reaction in water
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We report the aggregation-induced photosensitizing activity of a cyanine dye in water and the mechanism. In addition, using the supramolecular assembly, visible-light-driven photooxidation of hydrophobic aromatic compounds in water was successfully performed. This journal is
- Fujitsuka, Mamoru,Kida, Toshiyuki,Mori, Tadashi,Ohkubo, Kei,Osakada, Yasuko,Shigemitsu, Hajime,Tamemoto, Tomoe
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supporting information
p. 11217 - 11220
(2021/11/09)
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- A Study of the Favorskii Rearrangement with 3-Bromo-4-oxo-2,2,6,6-tetramethylpiperidin-1-oxyl
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Favorskii rearrangement reactions of the title compound with sodium hydroxide, sodium ethoxide, ammonia, several aliphatic amines, and ethyl sodiomalonate resulting in pyrrolidine nitroxyl radicals are described.
- Sosnovsky, George,Cai, Zhen-wei
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p. 3414 - 3418
(2007/10/02)
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