461665-33-8 Usage
Uses
Used in Pharmaceutical Industry:
4-[[2-Trifluoromethyl-1H-benzimidazol-1-yl]methyl]benzoic acid is used as a building block for the synthesis of biologically active molecules, given its unique structural properties and functional groups. Its potential applications in this industry include the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-[[2-Trifluoromethyl-1H-benzimidazol-1-yl]methyl]benzoic acid may be utilized as a precursor in the creation of novel agrochemicals, such as pesticides or herbicides, due to its chemical structure and potential biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 461665-33-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,1,6,6 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 461665-33:
(8*4)+(7*6)+(6*1)+(5*6)+(4*6)+(3*5)+(2*3)+(1*3)=158
158 % 10 = 8
So 461665-33-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H11F3N2O2/c17-16(18,19)15-20-12-3-1-2-4-13(12)21(15)9-10-5-7-11(8-6-10)14(22)23/h1-8H,9H2,(H,22,23)
461665-33-8Relevant articles and documents
Potent, exceptionally selective, orally bioavailable inhibitors of TNF-α Converting Enzyme (TACE): Novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1′ substituents
Ott, Gregory R.,Asakawa, Naoyuki,Lu, Zhonghui,Anand, Rajan,Liu, Rui-Qin,Covington, Maryanne B.,Vaddi, Krishna,Qian, Mingxin,Newton, Robert C.,Christ, David D.,Trzaskos, James M.,Duan, James J.-W.
, p. 1577 - 1582 (2008/12/21)
Novel ((2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamides were found to be excellent P1′ substituents in conjunction with unique constrained β-amino hydroxamic acid scaffolds for the discovery of potent selective inhibitors of TNF-α Converting Enzyme (TACE). Optimized examples proved potent for TACE, exceptionally selective over a wide panel of MMP and ADAM proteases, potent in the suppression of LPS-induced TNF-α in human whole blood and orally bioavailable.
