4629-04-3Relevant articles and documents
A Convenient Protocol for the Synthesis of Fatty Acid Amides
Johansson, Silje J. R.,Johannessen, Tonje,Ellefsen, Christiane F.,Ristun, Mali S.,Antonsen, Simen,Hansen, Trond V.,Stenstrom, Yngve,Nolsoe, Jens M. J.
supporting information, p. 213 - 217 (2019/01/14)
Several classes of biologically occurring fatty acid amides have been reported from mammalian and plant sources. Many amides conjugated with fatty acids of mammalian origin exhibit specific activation of individual receptors. Their potential as pharmacological tools or as lead compounds towards the development of novel therapeutics is of great interest. Hence, access to such amides by a practical, high-yielding and scalable protocol without affecting the geometry or position of sensitive functionalities is needed. A protocol that meets all these requirements involves activation of the corresponding acid with carbonyl diimidazole (CDI) followed by reaction with the desired amine or its hydrochloride. More than fifty compounds have been prepared in generally high yields.
Nano sulfated titania as solid acid catalyst in direct synthesis of fatty acid amides
Hosseini-Sarvari, Mona,Sodagar, Esmat,Doroodmand, Mohammad Mahdi
supporting information; experimental part, p. 2853 - 2859 (2011/05/17)
Nanosized sulfated titania was prepared by a sol-gel hydrothermal process. X-ray diffraction (XRD), transmission electron, and scanning electron micrographs (TEM and SEM), FT-IR specific surface area, and BET N2 adsorption were employed to characterize the properties of the synthesized sulfated TiO2. The results indicate that both anatase and rutile TiO2 are obtainable. This prepared sulfated titania showed high catalytic activity in direct amidation of fatty acids as well as benzoic acids with various amines under solvent-free conditions.
GC/MS investigations of the minor constituents of Piper guineense stem
Adesina,Adebayo,Adesina,Groening
, p. 622 - 627 (2007/10/03)
Chemical investigations by GC/MS-analysis of stem extracts of Piper guineense resulted in the detection and identification of thirty-nine new constituents of the stem, apart from previously isolated constituents. These are isobutyl, pyrrolidyl and piperidyl amide alkaloids. Fifteen new natural products have been identified. Four of these natural products have been designated iyeremide A and B (these are pyrrolidine and piperidine analogues of pellitorine) and cycloguineense A and B, which are also piperidine analogues of cyclostachine A and B. There is a need to confirm the structures of some of these new constituents by synthesis. Apart from these amide alkaloids, many volatile oil components-monoterpenes, sesquiterpenes, terpenoids, lignans and sterols - were detected.
Solid-supported chloro[1,3,5]triazine. A versatile new synthetic auxiliary for the synthesis of amide libraries
Masala, Simonetta,Taddei, Maurizio
, p. 1355 - 1357 (2008/02/09)
(equation presented) 2,4,6-Trichloro[1,3,5]triazine was loaded on different types of NH2-functionalized resins to give a new supported reagent. The best results, in term of yields products, were obtained using the chlorotriazine linked to a polystyrene-poly(ethylene glycol) resin. This reagent was employed for the solution-phase synthesis of different amides and dipeptides.
Preparation and Characterization of 1,5-Diacyl-2,4-dioxohexahydro-1,3,5-triazines with Higher Acyl Groups
Hofmann, Joerg,Just, Gerhard,Pritzkow, Wilhelm
, p. 67 - 71 (2007/10/02)
The title compounds were prepared from 2,4-dioxohexahydro-triazine (DHT) and the corresponding acid chlorides in the presence of sulphuric acid.They are active acylating agents against piperidine in dioxane as the solvent.Only the diacyl derivatives of DHT with acyl chain lengths up to C6 react with aqueous solutions of sodium perborate forming the corresponding peroxy acids.
A Convenient Preparation of Piperidinium Selenocarboxylates
Ishihara, Hideharu,Muto, Shinya,Kato, Shinzi
, p. 128 - 130 (2007/10/02)
Piperidinium selenocarboxylates were isolated from the reaction of bisdiselenides with piperidine in high yields.
