463337-53-3

Basic information

• Product Name: Ethanone, 1-(4-methoxy-2-pyrimidinyl)- (9CI)
• Synonyms: Ethanone, 1-(4-methoxy-2-pyrimidinyl)- (9CI);1-(4-methoxy-2-pyrimidinyl)Ethanone
• CAS NO: 463337-53-3
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15062
• Product Categories: ACETYLGROUP
• Mol File: 463337-53-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Ethanone, 1-(4-methoxy-2-pyrimidinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-methoxy-2-pyrimidinyl)- (9CI)(463337-53-3)
• EPA Substance Registry System: Ethanone, 1-(4-methoxy-2-pyrimidinyl)- (9CI)(463337-53-3)

Safety Data

• Hazardous Substances Data: 463337-53-3(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
Ethanone, 1-(4-methoxy-2-pyrimidinyl)(9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and properties may contribute to the development of new drugs with specific therapeutic effects.
Used in Pharmaceutical Research:
Ethanone, 1-(4-methoxy-2-pyrimidinyl)(9CI) is used as a research compound in the field of pharmaceuticals to study its biological activities and potential applications. Further research may help in understanding its interactions with biological targets and its role in the development of new therapeutic agents.
Used in Drug Design and Development:
Ethanone, 1-(4-methoxy-2-pyrimidinyl)(9CI) is used as a building block in the design and development of new drugs. Its structural features may be utilized to create novel drug candidates with improved pharmacological properties and therapeutic potential.
Used in Chemical Synthesis:
Ethanone, 1-(4-methoxy-2-pyrimidinyl)(9CI) is used as a reagent in various chemical synthesis processes. Its unique functional groups and properties may enable the synthesis of complex organic compounds with specific applications in different industries.

Upstream product

• 22536-63-6 2-chloro-4-methoxypyrimidine 
• 89640-54-0 2-iodo-4-methyoxypyrimidine 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 262353-35-5 2-iodo-4-methoxypyrimidine 

Relevant articles and documents

Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099)

AZD5099 (compound 63) is an antibacterial agent that entered phase 1 clinical trials targeting infections caused by Gram-positive and fastidious Gram-negative bacteria. It was derived from previously reported pyrrolamide antibacterials and a fragment-based approach targeting the ATP binding site of bacterial type II topoisomerases. The program described herein varied a 3-piperidine substituent and incorporated 4-thiazole substituents that form a seven-membered ring intramolecular hydrogen bond with a 5-position carboxylic acid. Improved antibacterial activity and lower in vivo clearances were achieved. The lower clearances were attributed, in part, to reduced recognition by the multidrug resistant transporter Mrp2. Compound 63 showed notable efficacy in a mouse neutropenic Staphylococcus aureus infection model. Resistance frequency versus the drug was low, and reports of clinical resistance due to alteration of the target are few. Hence, 63 could offer a novel treatment for serious issues of resistance to currently used antibacterials.

PIPERDINE COMPOUNDS AND USES THEREOF-911

Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.