- Mallotojaponins B and C: Total Synthesis, Antiparasitic Evaluation, and Preliminary SAR Studies
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(Chemical Equation Presented). The first total syntheses of mallotojaponin B and C as well as several analogues have been achieved. Biological evaluation of the synthesized compounds against Plasmodium falciparum and Trypanosoma brucei have also been carried out.
- Grayfer, Tatyana D.,Grellier, Philippe,Mouray, Elisabeth,Dodd, Robert H.,Dubois, Jo?lle,Cariou, Kevin
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supporting information
p. 708 - 711
(2016/03/01)
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- A facile synthesis of acetyl-hydroxy-2, 2-dimethylchromans and 2,2- dimethyl-2H-3,4-dihydropyranoflavanones - Dihydro mixtecacin, atalantoflavone dimethyl ether and racemoflavone dimethyl ether
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Synthesis of acetyl-hydroxy-2, 2-dimethyl chromans by thermal-Fries rearrangement of acetoxy-2, 2-dimethylchromans has been described. The reaction of acetyl-hydroxy chromans (2, 4 and 6) with aryl aldehyde in the presence of aqueous ethanolic potassium h
- Kumar,Rajendra Prasad
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p. 583 - 589
(2007/10/03)
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- Heterocycles: Part 7 - Synthesis of acetyl hydroxy-2,2-dimethylchromans
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Synthesis of acetyl hydroxy-2,2-dimethylchromans by two methods namely photo-Fries rearrangement of acetoxy-2,2-dimethylchromans (UV light, 253.7 nm) and Friedel-Crafts acetylation of hydroxy-2,2-dimethylchromans with gl. acetic acid using AlCl3/POCl3 has been described.
- Vijayalakshmi, C. S.,Shanmugam, P.,Prasad, K. J. Rajendra
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p. 510 - 511
(2007/10/02)
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- Convenient Synthesis of Alloevodione, Alloevodionol and Franklinone
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3,4-Dihydro-6-hydroxy-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (5), obtained by nuclear prenylation of 2,6-dimethoxyquinol, on methylation followed by Friedel-Crafts acetylation gives 8-acetyl-3,4-dihydro-7-hydroxy-5,6-dimethoxy-2,2-dimethyl-2H-1-benzopyran (7).Dehydrogenation of 7 with DDQ followed by methylation affords alloevodione (9).Similar isoprenylation of 2,6-dihydroxy-4-methoxyacetophenone gives a mixture of dichroman (10) and the monochroman (11).Dehydrogenation of 10 and 11 furnishes franklinone (3) and alloevodionol (1) respectively.
- Ahluwalia, V. K.,Jain, Anjula,Goyal, Madhuri
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p. 166 - 167
(2007/10/02)
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- ACID-CATALYZED CONDENSATION OF ISOPRENE AND 2-METHYLBUT-3-EN-2-OL WITH PHLOROACETOPHENONE, NEW SYNTHESIS OF ALLOEVODIONOL AND FRANKLINONE
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The naturally occurring acetylchromenes, alloevodionol (1) and franklinone (2) have been synthesized by the nuclear isoprenylation of phloroacetophenone followed by the partial methylation and dehydrogenation of the chromans thus obtained.
- Ahluwalia, V. K.,Arora, K. K.,Jolly, R. S.
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p. 117 - 120
(2007/10/02)
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- Hoesch Reaction of 3,4-Dihydro-2,2-dimethyl-2H-1-benzopyrans
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A reinvestigation of the Hoesch reaction of 3,4-dihydro-7-hydroxy- and 3,4-dihydro-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyrans (I and IV) with acetonitrile and hydrogen chloride reveals the formation of 6-acetyl (II) and 6,8-diacetyl (III) derivatives in the case of I, and 6-acetyl (V), 8-acetyl (VI) and 6,8-diacetyl (VII) derivatives in the case of IV.However, when a similar reaction is carried out on benzopyrans VIII and XI only mono-acetyl derivatives are obtained in each case, i. e.IX and X from VIII, and XII and XIII from XI.
- Prasad, K. J. Rajendra,Iyer, P. R.
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p. 255 - 256
(2007/10/02)
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